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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups ELUCIDATING THE INTRACELLULAR FATE OF THE NON-HUMAN SIALIC ACID N-GLYCOLYLNEURAMINIC ACID
TL;DR: It is shown that pre-loaded Neu5Gc is eliminated from human cells over time, and a conceivable Neu 5Gc-degrading pathway based on the well studied metabolism of N-acetylhexosamines is proposed, which is partially reversible.
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High level O-acetylation of sialic acids on N-linked oligosaccharides of rat liver membranes. Differential subcellular distribution of 7- and 9-O-acetyl groups and of enzymes involved in their regulation.
C. Butor,Sandra Diaz,Ajit Varki +2 more
TL;DR: This article showed that glycosidically bound sialic acids from total membranes of rat liver have surprisingly high levels (approximately 20%) of O-acetylation at the 7- or 9-position.
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Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution.
TL;DR: The data support a single origin of modern humans, but not with complete replacement of archaic inhabitants bymodern humans, and suggest interbreeding between then-contemporaneous human species.
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O-acetylation and de-O-acetylation of sialic acids. 7- and 9-o-acetylation of alpha 2,6-linked sialic acids on endogenous N-linked glycans in rat liver Golgi vesicles.
TL;DR: Results indicate that accumulation of free [3H]acetate occurs within the lumen of the vesicles in parallel with O-acetylation of sialic acids and is probably a product of abortive acetylation.
Journal ArticleDOI
Oligosaccharides in vertebrate development
Ajit Varki,Jamey D. Marth +1 more
TL;DR: A perspective on glycosylation in vertebrate development and experimental approaches towards elucidating oligosaccharide function are provided.