다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.

Inflammation and cancer

Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.

Integrins: versatility, modulation, and signaling in cell adhesion.

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Open access: the JCI has already shown it works

Effects of cervical dislocation on colony-forming cells in murine marrow cultures.

Intrinsically Hyperactive and Hyperproliferative CD8 + T Cells In Cmah -/- Mice as a Model of Human Gene Transfer Responses.

Editorial Following a 70-year-old tradition, The Journal of Clinical Investigation (JCI) will change hands again during March through April of this year, moving its editorial offices from La Jolla, California to Ann Arbor, Michigan. This tradition of editorial transitions ensures that JCI can reinvent itself every five years, and thereby adjust to the changing times. The selection of Stephen J. Weiss of the University of Michigan as the new Editor was the result of a nationwide search, in which detailed applications were submitted by many prospective candidates, who were nominated by their respective universities. The next issue of The Journal will carry an Editorial by Dr. Weiss, in which he will outline his plans for the next five years. We will focus here upon the modifications that the La Jolla group has made in the JCI during the last five years. The primary goal of the JCI is to publish original, high-quality work regarding human and mammalian biology, physiology , and medicine (the terms \" biology \" and \" physiology \" being interpreted in the broadest possible sense, to be inclusive of all types of research on humans). The Journal has remained in the top echelons of biomedical publications at least partly because of a tradition of thorough and critical reviews of submitted papers. However, many authors had previously regarded the review process as being too slow. When the La Jolla group took over, the previous Editors had already begun to streamline the handling of manuscripts (1). However, the JCI had also become a victim of its own success, and was experiencing an increased volume of manuscript submissions (see Fig. 1). We therefore instituted several changes aimed at improving the speed and efficiency of the review process, without compromising quality. These included the introduction of a uniform submission form, further computerization of manuscript tracking, liberal use of FAX and overnight mailing services , limitation of revisions to a single cycle, and the introduction of a screening review system for manuscripts. Of all these, the most novel (and consequently, the most controversial) was the screening review process. The rationale behind this system is outlined elsewhere (1, 2). Subsequent evaluation indicated that while not without its own flaws, this system appeared successful from the perspective of most authors, reviewers, and the editors (2, 3). If imitation is the sincerest form of flattery, it is interesting to note that many other journals have …

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Ajit Varki

Papers

Open access: the JCI has already shown it works

Effects of cervical dislocation on colony-forming cells in murine marrow cultures.

Intrinsically Hyperactive and Hyperproliferative CD8 + T Cells In Cmah -/- Mice as a Model of Human Gene Transfer Responses.

Passing the baton at high speed: time to hand over to a new editorial board.

Roland Schauer (1936–2019): A tribute to “Mr. Sialic Acid”