Ajit Varki

TL;DR: It is reported here that fast-atom bombardment-mass-spectrometry (FAB-MS) of native sialic acids provides specific detection and quantitation of many previously known compounds and shows that the alkaline conditions traditionally used for analytical de-O-acetylation of sIALic acids causes substantial conversion of 4,8-anhydro-N- acetyl-neuraminic acid in acid hydrolysates of horse serum.

TL;DR: It is shown that in the majority of patients administered 3 different types of cell-based therapies using cells grown in fetal calf serum-containing media, an antibody response to bovine apolipoprotein B-100 develops after the second infusion and is the dominant specificity.

TL;DR: GBS Sia has dual roles in counteracting platelet antimicrobial immunity: conferring intrinsic resistance to platelet-derived antimicrobial components and inhibiting platelet activation through engagement of inhibitory Siglecs.

TL;DR: An acetyl-coenzyme A: polysialosyl O-acetyltransferase activity that is found only in E. coli K1 OAc+ substrains is demonstrated, suggesting that enzymatic recognition of the substrate requires only thepolysialic acid sequence.

TL;DR: A study of serum myoglobin in a consecutive series of patients with suspected acute myocardial infarction, and in several other noncardiac conditions, finding the sensitivity, specificity, and practical value of SMb are discussed.