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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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N-Glycans -- Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
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Combinatorial Chemoenzymatic Synthesis and High-Throughput Screening of Sialosides
Harshal A. Chokhawala,Shengshu Huang,Kam Lau,Hai Yu,Jiansong Cheng,Vireak Thon,Nancy Hurtado-Ziola,Juan A. Guerrero,Ajit Varki,Xi Chen +9 more
TL;DR: High-throughput screening assays performed in NeutrAvidin-coated microtiter plates show that whereas Sambucus nigra Lectin binds to alpha2,6-linked sialosides with high promiscuity, human Siglec-2 (CD22) is highly selective for a number of sialic acid structures and the underlying glycans in its sIALoside ligands.
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A neuraminidase from Streptococcus sanguis that can release O-acetylated sialic acids.
Ajit Varki,Sandra Diaz +1 more
TL;DR: The general properties of this enzyme are described and its substrate specificities are contrasted with those of the commonly used neuraminidase from Vibrio cholerae.
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Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec‐5 and Siglec‐14
Jerry J. Fong,Karthik Sreedhara,Liwen Deng,Nissi Varki,Takashi Angata,Qinglian Liu,Victor Nizet,Ajit Varki +7 more
TL;DR: The results demonstrate that an endogenous non‐sialic acid‐bearing molecule can be either a danger‐associated or self‐associated signal through paired Siglecs, and may explain seemingly contradictory prior reports on extracellular Hsp70 action.
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Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis
Mai Zhang,Ajit Varki +1 more
TL;DR: The signal- modulating activity of CD22 Sia recognition cannot be explained by mediation of primary interactions with specific molecules, nor by effects on constitutive endocytosis, but could be of relevance to immunotoxin treatment of lymphomas.