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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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The Glycans of Stem Cells
TL;DR: The non-human sialic acid Neu5Gc has been detected on the surface of human embryonic stem cells because of metabolic incorporation from animal products used for their culture.
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Explaining human uniqueness: genome interactions with environment, behaviour and culture.
TL;DR: A genomic and genetic perspective towards molecular variation, systems analysis of gene expression and an organ-systems approach are explored, and it is speculated that aspects of human uniqueness arose because of a primate evolutionary trend towards increasing and irreversible dependence on learned behaviours and culture.
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Identification of a rat liver alpha-N-acetylglucosaminyl phosphodiesterase capable of removing "blocking" alpha-N-acetylglucosamine residues from phosphorylated high mannose oligosaccharides of lysosomal enzymes.
Ajit Varki,Stuart Kornfeld +1 more
TL;DR: This enzyme may be involved in the "unmasking" of the phosphomannosyl recognition marker on newly synthesized acid hydrolases which could then direct the targeting of these enzymes to lysosomes.
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Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates
TL;DR: The discovery of Siglec‐14, a novel sialic acid receptor undergoing concerted evolution with SigleC‐5 in primates is discovered, and near‐complete sequence identity of the amino‐terminal part of human SigLEC‐14 and SigLEc‐5 indicates partial gene conversion between SIGLEC14 and SIGleC5.
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Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms
TL;DR: These studies, which reflect one of the most complete comparative sequence analyses of a rapidly evolving gene cluster, provide a clearer picture of the ortholog status of CD33rSiglecs among primates and rodents and also facilitate rational recommendations regarding their nomenclature.