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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
Selective inactivation of influenza C esterase: a probe for detecting 9-O-acetylated sialic acids
Elaine A. Muchmore,Ajit Varki +1 more
TL;DR: DFP-treated INF-C bound specifically and irreversibly to cells expressing 9-O-acetylated sialic acids, providing a probe for a molecule that was hitherto very difficult to study.
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Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.
TL;DR: A comprehensive comparison of Siglecs between the human and mouse genomes found that this gene cluster underwent extensive duplications in the primate lineage thereafter, and supports a temporary lettered nomenclature for additional mouse Siglecus.
Glycosyltransferases and Glycan-Processing Enzymes
TL;DR: Glycosyltransferases and glycosidases are responsible for the assembly, processing, and turnover of glycans as mentioned in this paper, and there are a number of transferases that modify glycans by the addition of acetyl, methyl, phosphate, sulfate, and other groups.
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Biosynthesis and turnover of O-acetyl and N-acetyl groups in the gangliosides of human melanoma cells.
TL;DR: In this article, the melanoma-associated oncofetal glycosphingolipid antigen 9-O-acetyl-GD3, a disialoganglioside Oacetylated at the 9-position of the outer sialic acid residue, was examined.
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Structures of sialylated fucosyl polylactosaminoglycans isolated from chronic myelogenous leukemia cells.
TL;DR: The results indicate that chronic myelogenous leukemia cells express unique polylactosaminoglycan structures which are distinct from normal mature granulocytes.