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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids.
Zahra Khedri,An Xiao,Hai Yu,Corinna S. Landig,Wanqing Li,Sandra Diaz,Brian R. Wasik,Colin R. Parrish,Lee-Ping Wang,Ajit Varki,Xi Chen +10 more
TL;DR: A simple chemical biology solution to many of these problems by substituting the oxygen atom in the ester with a nitrogen atom, resulting in sialic acids with a chemically and biologically stable 9-N-acetyl group is demonstrated.
Journal ArticleDOI
Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence
Kurtis H. Feng,Gaelle Gonzalez,Lingquan Deng,Hai Yu,Victor L. Tse,Lu Huang,Kai Huang,Brian R. Wasik,Bin Zhou,David E. Wentworth,Edward C. Holmes,Xi Chen,Ajit Varki,Pablo R. Murcia,Colin R. Parrish +14 more
TL;DR: It is shown that although there were numerous genetic differences between the equine and canine viruses, this variation did not result in dramatic biological Differences between the viruses from the two hosts, and the viruses appeared phenotypically equivalent in most assays conducted.
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A sialic acid-specific O-acetylesterase in human erythrocytes: possible identity with esterase D, the genetic marker of retinoblastomas and Wilson disease.
TL;DR: Esterase D may be the first nonspecific esterase for which a specific biological role can be predicted and appears to be involved in the "recycling" of O-acetylated sialic acid molecules.
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Overview of glycoconjugate analysis.
TL;DR: This overview discusses the stereochemistry of monosaccharides and glycans and provides diagrammatic representations of monoaccharide representations (Fisher projections and Haworth representations) and formulas for representation of glycan chains.
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“Unusual” modifications and variations of vertebrate oligosaccharides: are we missing the flowers for the trees?
TL;DR: Vertebrate cells utilize a relatively limited subset of the monosaccharides known to exist in nature, and in only some of the many possible combinations, however, several unusual variations of the typical structures exist, as well as a variety of specific modifications of the individual monOSaccharide units.