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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
Papers
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Journal ArticleDOI
O-acetylation and de-O-acetylation of sialic acids. O-acetylation of sialic acids in the rat liver Golgi apparatus involves an acetyl intermediate and essential histidine and lysine residues--a transmembrane reaction?
TL;DR: Results indicate that the acetylation of sialic acids in Golgi vesicles may occur by a transmembrane reaction, similar to that described for the acetelation of glucosamine in lysosomes.
Journal ArticleDOI
Biotinylated diaminopyridine: an approach to tagging oligosaccharides and exploring their biology
TL;DR: A fluorescent reagent is synthesized, 2-amino-(6-amidobiotinyl)pyridine, which can tag oligosaccharides under nondegradative conditions with high efficiency and show excellent fractionation by reverse-phase HPLC with sensitive detection in the low picomole range.
Book ChapterDOI
Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain?
Leela R. L. Davies,Ajit Varki +1 more
TL;DR: The historical background to this issue is provided and potential mechanisms causing the suppression of Neu5Gc expression in brain tissue are discussed, as well as mechanisms by which Neu 5Gc may exert the presumed toxicity.
Journal ArticleDOI
Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.
Flavio Schwarz,Corinna S. Landig,Shoib S. Siddiqui,Ismael Secundino,Joshua Olson,Nissi Varki,Victor Nizet,Ajit Varki +7 more
TL;DR: Study of the inhibitory receptor Siglec‐11 shows uniquely human expression in brain microglia and engages endogenous polysialic acid to suppress inflammation and supports the long‐standing hypothesis that activating counterparts of paired immune receptors evolved as a response to pathogen molecular mimicry of host ligands for inhibitory receptors.
Journal ArticleDOI
Linkage-specific Action of Endogenous Sialic Acid O-Acetyltransferase in Chinese Hamster Ovary Cells
TL;DR: Results indicate that expression of sialic acid 9-O-acetylation can be regulated by the action of specific sialyltransferases that alter the predominant linkage of the terminal sIALic acids found on specific classes of glycoconjugates.