A
Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
Papers
More filters
Journal ArticleDOI
The biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked and O-linked glycans labeled by UDP-[6-3H]N-acetylgalactosamine.
Bradley K. Hayes,Ajit Varki +1 more
TL;DR: The results show the existence of a whole new class of GalNAc-containing N-linked oligosaccharides, and demonstrates that this in vitro approach can detect previously undescribed structures.
Journal ArticleDOI
Endo-glycosidase F and peptide N-glycosidase F release the great majority of total cellular N-linked oligosaccharides: use in demonstrating that sulfated N-linked oligosaccharides are frequently found in cultured cells.
Hudson H. Freeze,Ajit Varki +1 more
TL;DR: This treatment indeed released metabolically incorporated [35SO4] from each of 9 different cell lines demonstrating that sulfated N-linked oligosaccharides are much more common than previously believed.
Journal ArticleDOI
Chemical Diversity in the Sialic Acids and Related α‐Keto Acids: An Evolutionary Perspective
Takashi Angata,Ajit Varki +1 more
Journal ArticleDOI
Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera
Frederico Alisson-Silva,Janet Z. Liu,Sandra Diaz,Lingquan Deng,Mélanie G. Gareau,Ronald R. Marchelletta,Xi Chen,Victor Nizet,Victor Nizet,Nissi Varki,Kim E. Barrett,Ajit Varki +11 more
TL;DR: V. cholerae evolved into a human-specific pathogen partly by adapting to the human evolutionary loss of Neu5Gc, optimizing multiple steps in cholera pathogenesis.
Journal ArticleDOI
Molecular Cloning and Characterization of Lysosomal Sialic Acid O-Acetylesterase
M. Jorge Guimarães,J. Fernando Bazan,Janice Castagnola,Sandra Diaz,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,Ajit Varki,Albert Zlotnik +8 more
TL;DR: This constitutes the first report on the molecular cloning of a sialic acid-specific O-acetylesterase in vertebrates and suggests novel roles for the 9-O-acetyl modification of sIALic acids during the development and differentiation of mammalian organisms.