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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
Genomic Comparisons of Humans and Chimpanzees
Ajit Varki,David L. Nelson +1 more
TL;DR: A draft sequence of the chimpanzee genome is now available, providing opportunities to better understand genetic contributions to human evolution, development, and disease and a few examples of interesting findings resulting from genome-wide analyses, candidate gene studies, and combined approaches.
Microbial Lectins: Hemagglutinins, Adhesins, and Toxins
TL;DR: In this paper, the authors highlight examples of microbial lectins and their roles in pathogenicity, and discuss the mode of action of glycan-dependent toxins, including secreted toxins that use surface glycan targets for internalization by various mechanisms.
Journal ArticleDOI
Great Ape Phenome Project
Ajit Varki,Christopher Wills,David M. Perlmutter,David S. Woodruff,Fred H. Gage,Jim Moore,Katerina Semendeferi,Kurt Benirschke,Robert Katzman,Russell F. Doolittle,Theodore H. Bullock +10 more
TL;DR: It is suggested that the funding of such a Great Ape Genome Project should be complemented by a “Great Ape Phenome Project,” which would support comparative studies of humans and apes at all levels, from expression patterns of messenger RNA, to biochemistry and cell biology, all the way to neural systems and cognitive functions.
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Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation.
Preston S. K. Ng,Christopher J. Day,John M. Atack,Lauren E. Hartley-Tassell,Linda E. Winter,Linda E. Winter,Tal Marshanski,Vered Padler-Karavani,Ajit Varki,Stephen J. Barenkamp,Stephen J. Barenkamp,Michael A. Apicella,Michael P. Jennings +12 more
TL;DR: NTHi has evolved to preferentially utilize the Neu5Ac form of sialic acid, which allows NTHi to evade killing by a human antibody response against the nonhuman sIALic acid Neu 5Gc, and is shown to have a bias in a step of the LOS biosynthetic pathway.
Journal ArticleDOI
N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils
Anne K. Bergfeld,Roger Lawrence,Sandra Diaz,Oliver M. T. Pearce,Darius Ghaderi,Pascal Gagneux,Meave G. Leakey,Ajit Varki +7 more
TL;DR: In this paper, metabolic labeling experiments and studies of mice with human-like Neu5Gc deficiency were carried out and it was shown that Neu 5Gc degradation is the metabolic source of UDP-GlcNGc and UDP-GalNGc, and the latter allows an unexpectedly selective incorporation of N -glycolyl groups into chondroitin sulfate over other potential glycoconjugate products.