Ajit Varki

TL;DR: A single-step optical method for identification and quantification of different compositions of sialoglycans on glycoproteins and in serum by measuring and quantifying nanometal surface energy transfer (NSET) signals between quantum dots and gold nanoparticles bound to specific sIALic acid binding proteins (SBPs) and sialic acid moieties.

TL;DR: Glycosphingolipids (GSLs) as mentioned in this paper are amphipathic molecules with a polar glycan chain as a head group and a hydrophobic sphingosine-containing ceramide tail, which is typically embedded in the outer leaflet of the plasma membrane.

TL;DR: This work states that while the PSGL-1 polypeptide backbone is expressed in many cell types, it is only the correctly sialylated, fucosylation, and tyrosine-sulfated form found in certain cells that can function as a P-selectin ligand, and an excellent prior suggestion is to define the ligand as the glycan bound by the GBP.

TL;DR: The urgent need to bring the glycosciences back into the mainstream of biology by integrating relevant education into the curricula of medical, graduate, and postgraduate training programs, thus generating a critical sustainable workforce that can advance the much-needed translation of gly cosciences into a more complete understanding of biology and the enhanced practice of medicine.

TL;DR: Results indicate that these novel carboxylated N-glycans are constitutively expressed on vascular endothelium and participate in acute inflammatory responses by interaction with activated neutrophils.