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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR
Karina Hentrich,Karina Hentrich,Jonas Lofling,Anuj Pathak,Anuj Pathak,Victor Nizet,Victor Nizet,Ajit Varki,Birgitta Henriques-Normark,Birgitta Henriques-Normark +9 more
TL;DR: It is found that pneumococcal challenge in Cmah(-/-) mice leads to heightened bacterial loads, virulence, and NanA expression, and it is concluded that S. pneumoniae senses and responds to Neu5Ac, leading to CiaR activation and increased virulence and potentially explaining the greater susceptibility in humans.
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Chemoenzymatic Assembly of Mammalian O-Mannose Glycans
Caicai Meng,Aniruddha Sasmal,Yan Zhang,Tian Gao,Chang-Cheng Liu,Naazneen Khan,Ajit Varki,Fengshan Wang,Hongzhi Cao +8 more
TL;DR: A highly efficient chemoenzymatic strategy was developed that enabled the first collective synthesis of 63 core M1 and core M2 O-mannose glycans of α-dystroglycan, which are a causative factor for various muscular diseases.
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Inhibition of L- and P-selectin by a rationally synthesized novel core 2-like branched structure containing GalNAc-Lewisx and Neu5Acα2–3Galβ1–3GalNAc sequences
Rakesh K. Jain,Conrad F. Piskorz,Bao-Guo Huang,Robert D. Locke,Hui-Ling Han,Andrea Koenig,Ajit Varki,L Matta Khushi +7 more
TL;DR: A molecule is synthesized that is 5- to 6-fold better at inhibiting L- and P-selectin than sialyl Lewisx-OMe, by contrast to unbranched structures, substitution of a sulfate ester group for a sialic acid residue in such a molecule resulted in a considerable loss of inhibition ability.
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Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus
TL;DR: It is demonstrated that macrophages phagocytose the sialylated pathogen group B Streptococcus (GBS) and increase bactericidal activity via sialoadhesin-sialic-acid-mediated recognition.
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Regulation of Sialic Acid 9-O-Acetylation during the Growth and Differentiation of Murine Erythroleukemia Cells
TL;DR: 9-O-acetylation of sialic acids in murine erythroleukemia cells is a highly regulated modification, being selectively expressed in a cell type-specific manner on certain classes of oligosaccharides and differentially regulated with regard to subcellular localization and to the state of cellular differentiation.