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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk.
Annie N. Samraj,Kimberly A. Bertrand,Robert Luben,Zahra Khedri,Hai Yu,Dzung Nguyen,Christopher J. Gregg,Sandra Diaz,Sherilyn Sawyer,Sherilyn Sawyer,Xi Chen,Heather Eliassen,Heather Eliassen,Vered Padler-Karavani,Kana Wu,Kay-Tee Khaw,Walter C. Willett,Ajit Varki +17 more
TL;DR: The finding of a positive association of total anti-Neu5Gc antibodies with CRC risk also warrants confirmation in larger prospective studies, as these antibodies have potential as biomarkers for diseases associated with red meat consumption such as carcinomas, atherosclerosis, and type 2 diabetes.
Journal ArticleDOI
Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid
TL;DR: The conserved Neu5Gc-binding preference of these viruses likely plays a role in the natural history of the virus in vivo, and transcripts of CMAH are at very low levels in Western dog breed cells.
Journal ArticleDOI
O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence.
Shannon Weiman,Satoshi Uchiyama,Feng Ying C Lin,Donald O. Chaffin,Ajit Varki,Victor Nizet,Amanda L. Lewis,Amanda L. Lewis +7 more
TL;DR: Serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means are described and it is demonstrated that this subtle modification attenuates Gbs Sia-mediated neutrophil suppression and animal virulence.
Book ChapterDOI
Steps in the phosphorylation of the high mannose oligosaccharides of lysosomal enzymes.
TL;DR: It is proposed that the first enzyme in this scheme, N-acetylglucosaminylphosphotransferase, catalyses the initial, determining step by which newly synthesized acid hydrolases are distinguished from other newly synthesised glycoproteins and thus are eventually targeted to lysosomes.
Journal ArticleDOI
Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State.
Jonathan Okerblom,Flavio Schwarz,Josh Olson,Josh Olson,William Fletes,Syed Raza Ali,Syed Raza Ali,Paul T. Martin,Paul T. Martin,Christopher K. Glass,Victor Nizet,Victor Nizet,Ajit Varki +12 more
TL;DR: In innate immune responses in Cmah−/− mice are studied, emulating human loss of the gene encoding production of Neu5Gc, a major cell surface sialic acid, which likely had complex effects on immunity, providing greater capabilities to clear sublethal bacterial challenges, possibly at the cost of endotoxic shock risk.