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Andres Metspalu
Researcher at University of Tartu
Publications - 620
Citations - 123584
Andres Metspalu is an academic researcher from University of Tartu. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 144, co-authored 583 publications receiving 101156 citations. Previous affiliations of Andres Metspalu include Estonian Biocentre & Asper Biotech.
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Journal ArticleDOI
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
Chen Li,Svetlana Stoma,Luca A. Lotta,Sophie C Warner,Eva Albrecht,Alessandra Allione,Pascal P. Arp,Linda Broer,Jessica L. Buxton,Alexessander Couto Alves,Joris Deelen,Iryna O. Fedko,Scott D. Gordon,Tao Jiang,Robert Karlsson,Nicola D. Kerrison,Taylor K. Loe,Massimo Mangino,Yuri Milaneschi,Benjamin Miraglio,Natalia Pervjakova,Alessia Russo,Ida Surakka,Ashley van der Spek,Josine E. Verhoeven,Najaf Amin,Marian Beekman,Alexandra I. F. Blakemore,Federico Canzian,Stephen E. Hamby,Jouke-Jan Hottenga,Peter Jones,Pekka Jousilahti,Reedik Mägi,Sarah E. Medland,Grant W. Montgomery,Dale R. Nyholt,Markus Perola,Kirsi H. Pietiläinen,Veikko Salomaa,Elina Sillanpää,H. Eka D. Suchiman,Diana van Heemst,Gonneke Willemsen,Antonio Agudo,Heiner Boeing,Dorret I. Boomsma,María Dolores Chirlaque,Guy Fagherazzi,Pietro Ferrari,Paul W. Franks,Christian Gieger,Johan G. Eriksson,Marc J. Gunter,Sara Hägg,Iiris Hovatta,Liher Imaz,Jaakko Kaprio,Rudolf Kaaks,Timothy J. Key,Vittorio Krogh,Nicholas G. Martin,Olle Melander,Andres Metspalu,Concha Moreno,N. Charlotte Onland-Moret,Peter M. Nilsson,Ken K. Ong,Kim Overvad,Domenico Palli,Salvatore Panico,Nancy L. Pedersen,Brenda W.J.H. Penninx,J. Ramón Quirós,Marjo-Riitta Järvelin,Miguel Rodríguez-Barranco,Robert A. Scott,Gianluca Severi,P. Eline Slagboom,Tim D. Spector,Anne Tjønneland,Antonia Trichopoulou,Rosario Tumino,André G. Uitterlinden,Yvonne T. van der Schouw,Cornelia M. van Duijn,Elisabete Weiderpass,Eros Lazzerini Denchi,Giuseppe Matullo,Adam S. Butterworth,John Danesh,Nilesh J. Samani,Nicholas J. Wareham,Christopher P. Nelson,Claudia Langenberg,Veryan Codd,Veryan Codd +96 more
TL;DR: A genome-wide meta-analysis of LTL is performed by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals, replicating previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types.
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
Barbara Schormair,Chen Zhao,Steven Bell,Erik Tilch,Aaro V. Salminen,Benno Puetz,Yves Dauvilliers,Ambra Stefani,Birgit Hoegl,Werner Poewe,David Kemlink,Karel Sonka,Cornelius G. Bachmann,Walter Paulus,Claudia Trenkwalder,Wolfgang H. Oertel,Magdolna Hornyak,Maris Teder-Laving,Andres Metspalu,Georgios M. Hadjigeorgiou,Olli Polo,Ingo Fietze,Owen A. Ross,Zbigniew K. Wszolek,Adam S. Butterworth,Nicole Soranzo,Willem H. Ouwehand,David J. Roberts,John Danesh,Richard P. Allen,Christopher J. Earley,William G. Ondo,Lan Xiong,Jacques Montplaisir,Ziv Gan-Or,Markus Perola,Pavel Vodicka,Christian Dina,Andre Franke,Lukas Tittmann,Alexandre F.R. Stewart,Svati H. Shah,Christian Gieger,Annette Peters,Guy A. Rouleau,Klaus Berger,Konrad Oexle,Emanuele Di Angelantonio,David A. Hinds,Bertram Mueller-Myhsok,Juliane Winkelmann +50 more
Journal ArticleDOI
A genome-wide association study of early menopause and the combined impact of identified variants
John R. B. Perry,Tanguy Corre,Tõnu Esko,Daniel I. Chasman,Krista Fischer,Nora Franceschini,Chunyan He,Zoltán Kutalik,Massimo Mangino,Lynda M. Rose,Albert V. Smith,Lisette Stolk,Patrick Sulem,Michael N. Weedon,Wei V. Zhuang,Alice M. Arnold,Alan Ashworth,Sven Bergmann,Julie E. Buring,Andrea Burri,Constance Chen,Marilyn C. Cornelis,David Couper,Mark O. Goodarzi,Vilmundur Gudnason,Tamara B. Harris,Albert Hofman,Michael Jones,P. Kraft,Lenore J. Launer,Joop S.E. Laven,Guoan Li,Barbara McKnight,Corrado Masciullo,Lili Milani,Nick Orr,Bruce M. Psaty,Paul M. Ridker,Fernando Rivadeneira,Cinzia Sala,Andres Salumets,Minouk J. Schoemaker,Michela Traglia,Gérard Waeber,Stephen J. Chanock,Ellen W. Demerath,Melissa Garcia,Susan E. Hankinson,Frank B. Hu,David J. Hunter,Kathryn L. Lunetta,Andres Metspalu,Grant W. Montgomery,Joanne M. Murabito,Anne B. Newman,Ken K. Ong,Tim D. Spector,Kari Stefansson,Anthony J. Swerdlow,Unnur Thorsteinsdottir,Rob M. van Dam,André G. Uitterlinden,Jenny A. Visser,Peter Vollenweider,Daniela Toniolo,Anna Murray +65 more
TL;DR: EM has a genetic aetiology which overlaps variation in normal age at menopause and is at least partly explained by the additive effects of the same polygenic variants, and the combined effect of the common variants captured by the single nucleotide polymorphism arrays was estimated to account for ∼30% of the variance.
Journal ArticleDOI
Gene Expression Profiles of Non-Small Cell Lung Cancer: Survival Prediction and New Biomarkers
Kristjan Välk,Tõnu Vooder,Raivo Kolde,Mari-Ann Reintam,Cathleen Petzold,Jaak Vilo,Andres Metspalu +6 more
TL;DR: A significant correlation between RNA degradation and survival in adenocarcinoma cases is found and new candidate biomarker genes that are likely to be involved in diverse processes associated with NSCLC development are uncovered.
Journal ArticleDOI
Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study.
Wolfgang Ahrens,Wolfgang Ahrens,Hermann Pohlabeln,Ronja Foraita,Mari Nelis,Pagona Lagiou,Areti Lagiou,Christine Bouchardy,Alena Slamova,Miriam Schejbalova,Franco Merletti,Lorenzo Richiardi,Kristina Kjærheim,Antonio Agudo,Xavier Castellsagué,Tatiana V. Macfarlane,Gary J. Macfarlane,Yuan Chin Amy Lee,Renato Talamini,Luigi Barzan,Cristina Canova,Lorenzo Simonato,Peter Thomson,Patricia A. McKinney,Alex D. McMahon,Ariana Znaor,Claire M. Healy,Bernad E. McCartan,Andres Metspalu,Manuela Marron,Mia Hashibe,David I. Conway,Paul Brennan +32 more
TL;DR: Poor OH and DC seem to be independent risk factors for UADT because corresponding risk estimates remain substantially elevated after detailed adjustment for multiple confounders.