Barbara König

TL;DR: A genome-wide association study of lithium response in 2,563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen); the largest attempted so far finds a single locus of four linked SNPs on chromosome 21 met genome- wide significance criteria for association with lithium response.

TL;DR: A two-stage meta-analysis of GWAS of bipolar disorder patients and controls revealed genome-wide significant associations at two novel loci, adding to a growing list of common autosomal variants involved in BD and illustrating the power of comparing well-characterized cases to an excess of controls in GWAS.

TL;DR: Evidence is provided for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD, suggesting the potential for translational research aimed at personalized prescribing of lithium.

TL;DR: Lithium seems to offer some advantage over other medication over the long-term treatment of bipolar I and II disorder and patients tend to relapse with the same polarity as their index episode; this emphasizes the importance of the polarity concept.

TL;DR: The data underline the negative long-term impact of alcohol use disorders on bipolar disorder with more depressive bipolar I episodes and the importance of its detection and treatment.