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Benjamin A. Garcia
Researcher at University of Pennsylvania
Publications - 467
Citations - 40286
Benjamin A. Garcia is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 90, co-authored 425 publications receiving 31491 citations. Previous affiliations of Benjamin A. Garcia include Ludwig Maximilian University of Munich & Purdue University.
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Journal ArticleDOI
Tumour exosome integrins determine organotropic metastasis
Ayuko Hoshino,Bruno Costa-Silva,Tang-Long Shen,Gonçalo Rodrigues,Ayako Hashimoto,Milica Tesic Mark,Henrik Molina,Shinji Kohsaka,Angela Di Giannatale,Sophia Ceder,Swarnima Singh,Caitlin Williams,Nadine Soplop,Kunihiro Uryu,Lindsay A. Pharmer,Tari A. King,Linda Bojmar,Alexander E. Davies,Yonathan Ararso,Tuo Zhang,Haiying Zhang,Jonathan M. Hernandez,Joshua Mitchell Weiss,Vanessa D. Dumont-Cole,Kimberly Kramer,Leonard H. Wexler,Aru Narendran,Gary K. Schwartz,John H. Healey,Per Sandström,Knut Jørgen Labori,Elin H. Kure,Paul M. Grandgenett,Michael A. Hollingsworth,Maria de Sousa,Sukwinder Kaur,Maneesh Jain,Kavita Mallya,Surinder K. Batra,William R. Jarnagin,Mary S. Brady,Øystein Fodstad,Volkmar Müller,Klaus Pantel,Andy J. Minn,Mina J. Bissell,Benjamin A. Garcia,Yibin Kang,Yibin Kang,Vinagolu K. Rajasekhar,Cyrus M. Ghajar,Irina Matei,Héctor Peinado,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +55 more
TL;DR: It is demonstrated that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells.
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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Héctor Peinado,Maša Alečković,Simon Lavotshkin,Irina Matei,Bruno Costa-Silva,Gema Moreno-Bueno,Marta Hergueta-Redondo,Caitlin Williams,Guillermo García-Santos,Cyrus M. Ghajar,Ayuko Nitadori-Hoshino,Caitlin Hoffman,Karen Badal,Benjamin A. Garcia,Margaret K. Callahan,Jianda Yuan,Vilma R. Martins,Johan Skog,Rosandra N. Kaplan,Mary S. Brady,Jedd D. Wolchok,Jedd D. Wolchok,Paul B. Chapman,Paul B. Chapman,Yibin Kang,Yibin Kang,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +28 more
TL;DR: The data show that exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis, has prognostic value and offers promise for new therapeutic directions in the metastatic process.
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Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
Peter W. Lewis,Manuel M. Müller,Matthew S. Koletsky,Francisco Cordero,Shu Lin,Laura A. Banaszynski,Benjamin A. Garcia,Tom W. Muir,Oren J. Becher,C. David Allis +9 more
TL;DR: It is proposed that K-to-M substitutions may represent a mechanism to alter epigenetic states in a variety of pathologies and be sufficient to cause specific reduction in methylation through inhibition of SET-domain enzymes.
Journal ArticleDOI
Regulation of HP1–chromatin binding by histone H3 methylation and phosphorylation
Wolfgang Fischle,Boo Shan Tseng,Holger L. Dormann,Beatrix Ueberheide,Benjamin A. Garcia,Jeffrey Shabanowitz,Donald F. Hunt,Hironori Funabiki,C. David Allis +8 more
TL;DR: It is shown that HP1α, -β, and -γ are released from chromatin during the M phase of the cell cycle, even though tri-methylation levels of histone H3 lysine 9 remain unchanged, and a regulatory mechanism of protein–protein interactions is established through a combinatorial readout of two adjacent post-translational modifications: a stable methylation and a dynamic phosphorylation mark.
Journal ArticleDOI
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Zhixun Dou,Kanad Ghosh,Maria Grazia Vizioli,Jiajun Zhu,Payel Sen,Kirk J. Wangensteen,Johayra Simithy,Yemin Lan,Yanping Lin,Zhuo Zhou,Brian C. Capell,Caiyue Xu,Mingang Xu,Julia E. Kieckhaefer,Tianying Jiang,Michal Shoshkes-Carmel,K M Ahasan Al Tanim,Glen N. Barber,John T. Seykora,Sarah E. Millar,Klaus H. Kaestner,Benjamin A. Garcia,Peter D. Adams,Peter D. Adams,Shelley L. Berger +24 more
TL;DR: It is shown that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING (cyclic GMP–AMP synthase linked to stimulator of interferon genes) pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.