C
Canary Pass Investigators
Researcher at Fred Hutchinson Cancer Research Center
Publications - 5
Citations - 81
Canary Pass Investigators is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Hazard ratio & Prostate cancer. The author has an hindex of 3, co-authored 5 publications receiving 27 citations. Previous affiliations of Canary Pass Investigators include University of Washington & Vanderbilt University Medical Center.
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Journal ArticleDOI
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
Minh-Phuong Huynh-Le,Chun Chieh Fan,Roshan Karunamuni,Wesley K. Thompson,Maria Elena Martinez,Rosalind A. Eeles,Zsofia Kote-Jarai,Kenneth Muir,Kenneth Muir,Johanna Schleutker,Johanna Schleutker,Nora Pashayan,Nora Pashayan,Jyotsna Batra,Jyotsna Batra,Henrik Grönberg,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Freddie C. Hamdy,Richard M. Martin,Richard M. Martin,Richard M. Martin,Sune F. Nielsen,Sune F. Nielsen,Børge G. Nordestgaard,Børge G. Nordestgaard,Fredrik Wiklund,Catherine M. Tangen,Graham G. Giles,Graham G. Giles,Graham G. Giles,Alicja Wolk,Alicja Wolk,Demetrius Albanes,Ruth C. Travis,William J. Blot,Wei Zheng,Maureen Sanderson,Janet L. Stanford,Janet L. Stanford,Lorelei A. Mucci,Catharine M L West,Adam S. Kibel,Olivier Cussenot,Sonja I. Berndt,Stella Koutros,Karina Dalsgaard Sørensen,Karina Dalsgaard Sørensen,Cezary Cybulski,Eli Marie Grindedal,Florence Menegaux,Florence Menegaux,Kay-Tee Khaw,Jong Y. Park,Sue A. Ingles,Christiane Maier,Robert J. Hamilton,Robert J. Hamilton,Stephen N. Thibodeau,Barry S. Rosenstein,Yong-Jie Lu,Stephen Watya,Ana Vega,Manolis Kogevinas,Kathryn L. Penney,Chad D. Huff,Manuel R. Teixeira,Luc Multigner,Robin J. Leach,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hermann Brenner,Esther M. John,Radka Kaneva,Christopher J. Logothetis,Susan L. Neuhausen,Kim De Ruyck,Hardev Pandha,Azad Hassan Abdul Razack,Lisa F. Newcomb,Lisa F. Newcomb,Jay H. Fowke,Jay H. Fowke,Marija Gamulin,Nawaid Usmani,Nawaid Usmani,Frank Claessens,Manuela Gago-Dominguez,Paul A. Townsend,William S. Bush,Monique J. Roobol,Marie-Élise Parent,Marie-Élise Parent,Jennifer J. Hu,Ian G. Mills,Ole A. Andreassen,Anders M. Dale,Tyler M. Seibert,Apcb,Nc-La PCaP Investigators,Canary Pass Investigators +102 more
TL;DR: In this paper, a polygenic hazard score (PHS2) is associated with age at diagnosis of any and aggressive prostate cancer, stage T3-T4, PSA ≥ 10 ng/mL or nodal/distant metastasis.
Posted ContentDOI
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
Minh-Phuong Huynh-Le,Minh-Phuong Huynh-Le,Chun Chieh Fan,R. Karunamuni,R. Karunamuni,Wesley K. Thompson,Maria Elena Martinez,Rosalind A. Eeles,Rosalind A. Eeles,Zsofia Kote-Jarai,Kenneth Muir,Kenneth Muir,Johanna Schleutker,Johanna Schleutker,Nora Pashayan,Nora Pashayan,Jyotsna Batra,Jyotsna Batra,Apcb,Apcb,Henrik Grönberg,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Freddie C. Hamdy,Richard M. Martin,Richard M. Martin,Richard M. Martin,Sune F. Nielsen,Sune F. Nielsen,Børge G. Nordestgaard,Børge G. Nordestgaard,Fredrik Wiklund,Catherine M. Tangen,Graham G. Giles,Graham G. Giles,Graham G. Giles,Alicja Wolk,Alicja Wolk,Demetrius Albanes,Ruth C. Travis,William J. Blot,Wei Zheng,Maureen Sanderson,Janet L. Stanford,Janet L. Stanford,Lorelei A. Mucci,Catharine M L West,Adam S. Kibel,Olivier Cussenot,Sonja I. Berndt,Stella Koutros,Karina Dalsgaard Sørensen,Karina Dalsgaard Sørensen,Cezary Cybulski,Eli Marie Grindedal,Florence Menegaux,Florence Menegaux,Kay-Tee Khaw,Jong Y. Park,Sue A. Ingles,Christiane Maier,Robert J. Hamilton,Robert J. Hamilton,Stephen N. Thibodeau,Barry S. Rosenstein,Yong-Jie Lu,Stephen Watya,Ana Vega,Nc-La PCaP Investigators,Manolis Kogevinas,Kathryn L. Penney,Chad Huff,Manuel R. Teixeira,Luc Multigner,Robin J Leach,Robin J Leach,Lisa Cannon-Albright,Hermann Brenner,Esther M. John,Radka Kaneva,Christopher J. Logothetis,Susan L. Neuhausen,Kim De Ruyck,Hardev Pandha,Azad Razack,Azad Razack,Lisa F. Newcomb,Lisa F. Newcomb,Canary Pass Investigators,Jay H. Fowke,Marija Gamulin,Nawaid Usmani,Frank Claessens,Manuela Gago-Dominguez,Paul A. Townsend,William S. Bush,Shiv Srivastava,Monique J Roobol,Monique J Roobol,Marie-Élise Parent,Jennifer J. Hu,Ian G. Mills,Ole A. Andreassen,Anders M. Dale,Anders M. Dale,Tyler M. Seibert +107 more
TL;DR: Genetic risk stratification via PHS could guide individualized screening and treatment strategies for fatal and potentially fatal prostate cancer for men of European, Asian, and African genetic ancestry.
Journal ArticleDOI
The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor
Andreia Brandão,Paula Paulo,Sofia Maia,Manuela Pinheiro,Ana Peixoto,Marta Cardoso,Maria P. Silva,Catarina Santos,Rosalind A. Eeles,Zsofia Kote-Jarai,Kenneth Muir,Johanna Schleutker,Ying Wang,Nora Pashayan,Jyotsna Batra,Apcb BioResource,Apcb BioResource,Henrik Grönberg,David E. Neal,Børge G. Nordestgaard,Catherine M. Tangen,Melissa C. Southey,Alicja Wolk,Demetrius Albanes,Christopher A. Haiman,Ruth C. Travis,Janet L. Stanford,Lorelei A. Mucci,Catharine M L West,Sune F. Nielsen,Sune F. Nielsen,Adam S. Kibel,Olivier Cussenot,Sonja I. Berndt,Stella Koutros,Karina Dalsgaard Sørensen,Cezary Cybulski,Eli Marie Grindedal,Jong Y. Park,Sue A. Ingles,Christiane Maier,Robert J. Hamilton,Barry S. Rosenstein,Ana Vega,Manolis Kogevinas,Fredrik Wiklund,Kathryn L. Penney,Hermann Brenner,Esther M. John,Radka Kaneva,Christopher J. Logothetis,Susan L. Neuhausen,Kim De Ruyck,Azad Hassan Abdul Razack,Lisa F. Newcomb,Lisa F. Newcomb,Canary Pass Investigators,Canary Pass Investigators,Davor Lessel,Nawaid Usmani,Frank Claessens,Manuela Gago-Dominguez,Paul A. Townsend,Monique J. Roobol,Manuel R. Teixeira +64 more
TL;DR: The results clearly demonstrate that c.349A>G in the CHEK2 tumour-suppressor gene is a founder variant significantly associated with an increased risk of PrCa, suggesting its potential usefulness for cost-effective targeted genetic screening in PrCa families.
Posted ContentDOI
Additional SNPs improve the performance of a polygenic hazard score for prostate cancer
Roshan Karunamuni,Minh-Phuong Huynh-Le,Chun Chieh Fan,Wesley K. Thompson,Rosalind A. Eeles,Zsofia Kote-Jarai,Kenneth Muir,Artitaya Lophatananon,Johanna Schleutker,Nora Pashayan,Jyotsna Batra,Apcb BioResource,Henrik Grönberg,Eleanor I Walsh,Emma L Turner,Athene Lane,Richard M. Martin,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Børge G. Nordestgaard,Catherine M. Tangen,Robert J. MacInnis,Alicja Wolk,Demetrius Albanes,Christopher A. Haiman,Ruth C. Travis,Janet L. Stanford,Lorelei A. Mucci,Catharine M L West,Sune F. Nielsen,Adam S. Kibel,Fredrik Wiklund,Olivier Cussenot,Sonja I. Berndt,Stella Koutros,Karina Dalsgaard Sørensen,Cezary Cybulski,Eli Marie Grindedal,Jong Y. Park,Sue A. Ingles,Christiane Maier,Robert J. Hamilton,Barry Rossenstein,Ana Vega,Manolis Kogevinas,Kathryn L. Penney,Manuel R. Teixeira,Hermann Brenner,Esther M. John,Radka Kaneva,Christopher J. Logothetis,Susan L. Neuhausen,Azad Razack,Lisa F. Newcomb,Canary Pass Investigators,Marija Gamulin,Nawaid Usmani,Frank Claessens,Manuela Gago-Dominguez,Paul A. Townsend,Monique J Roobol,Wei Zheng,Ian G. Mills,Ole A. Andreassen,Anders M. Dale,Tyler M. Seibert +66 more
TL;DR: Incorporating 120 additional SNPs significantly improved HRs for prostate cancer, while PPV of PSA testing for clinically significant prostate cancer remained the same.
Posted ContentDOI
Prostate cancer risk stratification improved across multiple ancestries with new polygenic hazard score
Minh-Phuong Huynh-Le,Minh-Phuong Huynh-Le,Roshan Karunamuni,Chun Chieh Fan,Lui Asona,Wesley K. Thompson,Maria Elena Martinez,Rosalind A. Eeles,Rosalind A. Eeles,Zsofia Kote-Jarai,Kenneth Muir,Artitaya Lophatananon,Johanna Schleutker,Johanna Schleutker,Nora Pashayan,Nora Pashayan,Jyotsna Batra,Jyotsna Batra,Henrik Grönberg,David E. Neal,David E. Neal,Børge G. Nordestgaard,Børge G. Nordestgaard,Catherine M. Tangen,Robert J. MacInnis,Robert J. MacInnis,Alicja Wolk,Demetrius Albanes,Christopher A. Haiman,Ruth C. Travis,William J. Blot,Janet L. Stanford,Janet L. Stanford,Lorelei A. Mucci,Catharine M L West,Sune F. Nielsen,Sune F. Nielsen,Adam S. Kibel,Olivier Cussenot,Sonja I. Berndt,Stella Koutros,Karina Dalsgaard Sørensen,Karina Dalsgaard Sørensen,Cezary Cybulski,Eli Marie Grindedal,Florence Menegaux,Jong Y. Park,Sue A. Ingles,Christiane Maier,Robert J. Hamilton,Robert J. Hamilton,Barry S. Rosenstein,Yong-Jie Lu,Stephen Watya,Ana Vega,Manolis Kogevinas,Fredrik Wiklund,Kathryn L. Penney,Chad D. Huff,Manuel R. Teixeira,Luc Multigner,Robin J. Leach,Hermann Brenner,Esther M. John,Radka Kaneva,Christopher J. Logothetis,Susan L. Neuhausen,Kim De Ruyck,Piet Ost,Azad Hassan Abdul Razack,Lisa F. Newcomb,Lisa F. Newcomb,Jay H. Fowke,Marija Gamulin,Aswin George Abraham,Frank Claessens,Jose E. Castelao,Paul A Townsend,Paul A Townsend,Dana C. Crawford,Gyorgy Petrovics,Ron H.N. van Schaik,Marie-Élise Parent,Marie-Élise Parent,Jennifer J. Hu,Wei Zheng,Ian G. Mills,Ole A. Andreassen,Anders M. Dale,Anders M. Dale,Tyler M. Seibert,Apcb,Nc-La PCaP Investigators,Canary Pass Investigators +93 more
TL;DR: In this article, the authors evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in multi-ancestry datasets.