Delphine Bacq-Daian

TL;DR: The results confirm the potential of FFPE samples analysis for clinical genomic studies, but also indicate that the choice of a FFPe DNA extraction kit should be done with careful testing and analysis beforehand in order to maximize the accuracy of the results.

TL;DR: In this article, the authors conducted the largest genome-wide association study performed so far in DCM, with 2719 cases and 4440 controls in the discovery population, and identified and replicated two new DCM-associated loci on chromosome 3p25.1 and chromosome 22q11.23.

TL;DR: Evidence of sex-specific associations in RCC genetic susceptibility is provided and the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC is advocated.

TL;DR: Using a comprehensive analysis based on a family cohort, including the data of multiple visits and GRM, it is found that HR variability is about 25% from genetic origin,25% from repeated measures and 50% remains unexplained.

TL;DR: Higher PCSK9 concentration was associated with the development of arterial plaques almost 20 years in advance in a healthy middle‐aged population and could be useful for primary cardiovascular prevention.