G
Goya Wanamethee
Researcher at University College London
Publications - 2
Citations - 315
Goya Wanamethee is an academic researcher from University College London. The author has contributed to research in topics: Case-control study & Odds ratio. The author has an hindex of 2, co-authored 2 publications receiving 251 citations.
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Journal ArticleDOI
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
Amand F. Schmidt,Daniel I. Swerdlow,Daniel I. Swerdlow,Michael V. Holmes,Michael V. Holmes,Riyaz S. Patel,Riyaz S. Patel,Zammy Fairhurst-Hunter,Donald M. Lyall,Fernando Pires Hartwig,Bernardo L. Horta,Elina Hyppönen,Elina Hyppönen,Christine Power,Max Moldovan,Max Moldovan,Erik P A Van Iperen,G. Kees Hovingh,Ilja Demuth,Kristina Norman,Elisabeth Steinhagen-Thiessen,Juri Demuth,Lars Bertram,Lars Bertram,Tian Liu,Stefan Coassin,Johann Willeit,Stefan Kiechl,Karin Willeit,Dan Mason,John Wright,Richard W Morris,Goya Wanamethee,Peter H. Whincup,Yoav Ben-Shlomo,Stela McLachlan,Jackie F. Price,Mika Kivimäki,Catherine Welch,Adelaida Sanchez-Galvez,Pedro Marques-Vidal,Andrew N. Nicolaides,Andrew N. Nicolaides,Andrie G. Panayiotou,N. Charlotte Onland-Moret,Yvonne T. van der Schouw,Giuseppe Matullo,Giovanni Fiorito,Simonetta Guarrera,Carlotta Sacerdote,Nicholas J. Wareham,Claudia Langenberg,Robert A. Scott,Jian'an Luan,Martin Bobak,Sofia Malyutina,Andrzej Pająk,Ruzena Kubinova,Abdonas Tamosiunas,Hynek Pikhart,Lise Lotte N. Husemoen,Niels Grarup,Oluf Pedersen,Torben Hansen,Allan Linneberg,Kenneth Starup Simonsen,Jackie A. Cooper,Steve E. Humphries,Murray H. Brilliant,Terrie Kitchner,Hakon Hakonarson,David Carrell,Catherine A. McCarty,H. Lester Kirchner,Eric B. Larson,David R. Crosslin,Mariza de Andrade,Dan M. Roden,Joshua C. Denny,Cara L. Carty,Stephen Hancock,John Attia,Elizabeth G. Holliday,Martin O'Donnell,Salim Yusuf,Michael Chong,Guillaume Paré,Pim van der Harst,M. Abdullah Said,Ruben N. Eppinga,Niek Verweij,Harold Snieder,Tim Christen,Dennis O. Mook-Kanamori,Stefan Gustafsson,Lars Lind,Erik Ingelsson,Erik Ingelsson,Erik Ingelsson,Raha Pazoki,Oscar H. Franco,Albert Hofman,André G. Uitterlinden,Abbas Dehghan,Abbas Dehghan,Alexander Teumer,Sebastian E. Baumeister,Sebastian E. Baumeister,Marcus Dörr,Markus M. Lerch,Uwe Völker,Henry Völzke,Joey Ward,Jill P. Pell,Daniel J. Smith,Tom W. Meade,Anke H. Maitland-van der Zee,Ekaterina V Baranova,Robin Young,Ian Ford,Archie Campbell,Sandosh Padmanabhan,Michiel L. Bots,Diederick E. Grobbee,Philippe Froguel,Philippe Froguel,Dorothée Thuillier,Beverley Balkau,Amélie Bonnefond,Amélie Bonnefond,Bertrand Cariou,Melissa C. Smart,Yanchun Bao,Meena Kumari,Anubha Mahajan,Paul M. Ridker,Daniel I. Chasman,Alexander P. Reiner,Leslie A. Lange,Marylyn D. Ritchie,Marylyn D. Ritchie,Folkert W. Asselbergs,Juan-Pablo Casas,Brendan J. Keating,David Preiss,David Preiss,Aroon D. Hingorani,Naveed Sattar +147 more
TL;DR: PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes.
Journal ArticleDOI
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Amand F. Schmidt,Amand F. Schmidt,Michael V. Holmes,David Preiss,Daniel I. Swerdlow,Daniel I. Swerdlow,Spiros Denaxas,Spiros Denaxas,Ghazaleh Fatemifar,Rupert Faraway,Chris Finan,Dennis Valentine,Zammy Fairhurst-Hunter,Fernando Pires Hartwig,Bernardo L. Horta,Elina Hyppönen,Elina Hyppönen,Christine Power,Max Moldovan,Erik P A Van Iperen,Kees Hovingh,Ilja Demuth,Kristina Norman,Kristina Norman,Elisabeth Steinhagen-Thiessen,Juri Demuth,Lars Bertram,Lars Bertram,Christina M. Lill,Christina M. Lill,Stefan Coassin,Johann Willeit,Stefan Kiechl,Karin Willeit,Karin Willeit,Dan Mason,John Wright,Richard W Morris,Goya Wanamethee,Peter H. Whincup,Yoav Ben-Shlomo,Stela McLachlan,Jackie F. Price,Mika Kivimäki,Catherine Welch,Adelaida Sanchez-Galvez,Pedro Marques-Vidal,Andrew N. Nicolaides,Andrew N. Nicolaides,Andrie G. Panayiotou,N. Charlotte Onland-Moret,Yvonne T. van der Schouw,Giuseppe Matullo,Giovanni Fiorito,Simonetta Guarrera,Carlotta Sacerdote,Nicholas J. Wareham,Claudia Langenberg,Robert A. Scott,Jian'an Luan,Martin Bobak,Sofia Malyutina,Andrzej Pajak,Ruzena Kubinova,Abdonas Tamosiunas,Hynek Pikhart,Niels Grarup,Oluf Pedersen,Torben Hansen,Allan Linneberg,Tine Jess,Jackie A. Cooper,Steve E. Humphries,Murray H. Brilliant,Terrie Kitchner,Hakon Hakonarson,David Carrell,Catherine A. McCarty,Kirchner H. Lester,Eric B. Larson,David R. Crosslin,Mariza de Andrade,Dan M. Roden,Joshua C. Denny,Cara L. Carty,Stephen Hancock,John Attia,Elizabeth G. Holliday,Rodney J. Scott,Peter W. Schofield,Martin O'Donnell,Salim Yusuf,Michael Chong,Guillaume Paré,Pim van der Harst,Pim van der Harst,M. Abdullah Said,Ruben N. Eppinga,Niek Verweij,Harold Snieder,Tim Christen,Dennis O. Mook-Kanamori,Stefan Gustafsson,Lars Lind,Lars Lind,Erik Ingelsson,Erik Ingelsson,Raha Pazoki,Raha Pazoki,Oscar H. Franco,Albert Hofman,André G. Uitterlinden,Abbas Dehghan,Alexander Teumer,Sebastian E. Baumeister,Sebastian E. Baumeister,Marcus Dörr,Markus M. Lerch,Uwe Völker,Henry Völzke,Joey Ward,Jill P. Pell,Tom W. Meade,Ingrid E. Christophersen,Anke H. Maitland-van der Zee,Anke H. Maitland-van der Zee,Ekaterina V. Baranova,Robin Young,Ian Ford,Archie Campbell,Sandosh Padmanabhan,Michiel L. Bots,Diederick E. Grobbee,Philippe Froguel,Philippe Froguel,Dorothée Thuillier,Ronan Roussel,Amélie Bonnefond,Bertrand Cariou,Melissa C. Smart,Yanchun Bao,Meena Kumari,Anubha Mahajan,Jemma C. Hopewell,Sudha Seshadri,Caroline Dale,Rui Bebiano Da Providencia E Costa,Paul M. Ridker,Daniel I. Chasman,Alexander P. Reiner,Marylyn D. Ritchie,Leslie A. Lange,Alex J. Cornish,Sara E. Dobbins,Kari Hemminki,Ben Kinnersley,Marc Sanson,Karim Labreche,Matthias Simon,Melissa L. Bondy,Philip J. Law,Helen E. Speedy,James M. Allan,Ni Li,Molly Went,Niels Weinhold,Gareth J. Morgan,Pieter Sonneveld,Björn Nilsson,Hartmut Goldschmidt,Amit Sud,Andreas Engert,Markus Hansson,Harry Hemingway,Folkert W. Asselbergs,Folkert W. Asselbergs,Riyaz S. Patel,Riyaz S. Patel,Brendan J. Keating,Naveed Sattar,Richard S. Houlston,Juan P. Casas,Aroon D. Hingorani +182 more
TL;DR: Genetic variation at thePCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI, while indicating an increased risk of type 2 diabetes mellitus and no other possible safety concerns were shown.