D
Diederick E. Grobbee
Researcher at Utrecht University
Publications - 3
Citations - 1234
Diederick E. Grobbee is an academic researcher from Utrecht University. The author has contributed to research in topics: Lower risk & Alcohol abuse. The author has an hindex of 3, co-authored 3 publications receiving 837 citations. Previous affiliations of Diederick E. Grobbee include European Society of Cardiology & University Medical Center Utrecht.
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Journal ArticleDOI
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
Angela M. Wood,Stephen Kaptoge,Adam S. Butterworth,Peter Willeit,Samantha Warnakula,Thomas Bolton,Ellie Paige,Dirk S. Paul,Michael J. Sweeting,Stephen Burgess,Steven Bell,William J. Astle,David Stevens,Albert Koulman,Randi Selmer,W. M. Monique Verschuren,Shinichi Sato,Inger Njølstad,Mark Woodward,Mark Woodward,Mark Woodward,Veikko Salomaa,Børge G. Nordestgaard,Børge G. Nordestgaard,Bu B. Yeap,Bu B. Yeap,Bu B. Yeap,Astrid E. Fletcher,Olle Melander,Lewis H. Kuller,B. Balkau,Michael Marmot,Wolfgang Koenig,Wolfgang Koenig,Edoardo Casiglia,Cyrus Cooper,Volker Arndt,Oscar H. Franco,Patrik Wennberg,John Gallacher,Agustín Gómez de la Cámara,Henry Völzke,Christina C. Dahm,Caroline Dale,Manuela M. Bergmann,Carlos J. Crespo,Yvonne T. van der Schouw,Rudolf Kaaks,Leon A. Simons,Pagona Lagiou,Pagona Lagiou,Josje D. Schoufour,Jolanda M. A. Boer,Timothy J. Key,Beatriz L. Rodriguez,Conchi Moreno-Iribas,Karina W. Davidson,James O. Taylor,Carlotta Sacerdote,Robert B. Wallace,J. Ramón Quirós,Rosario Tumino,Dan G. Blazer,Allan Linneberg,Makoto Daimon,Salvatore Panico,Barbara V. Howard,Guri Skeie,Timo E. Strandberg,Timo E. Strandberg,Elisabete Weiderpass,Paul J. Nietert,Bruce M. Psaty,Bruce M. Psaty,Daan Kromhout,Elena Salamanca-Fernández,Stefan Kiechl,Harlan M. Krumholz,Sara Grioni,Domenico Palli,José María Huerta,Jackie F. Price,Johan Sundström,Larraitz Arriola,Hisatomi Arima,Hisatomi Arima,Ruth C. Travis,Demosthenes B. Panagiotakos,Anna Karakatsani,Antonia Trichopoulou,Tilman Kühn,Diederick E. Grobbee,Elizabeth Barrett-Connor,Natasja M. van Schoor,Heiner Boeing,Kim Overvad,Kim Overvad,Jussi Kauhanen,Nicholas J. Wareham,Claudia Langenberg,Nita G. Forouhi,Maria Wennberg,Jean-Pierre Després,Mary Cushman,Jackie A. Cooper,Carlos J. Rodriguez,Carlos J. Rodriguez,Masaru Sakurai,Jonathan E. Shaw,Matthew Knuiman,Trudy Voortman,Christa Meisinger,Anne Tjønneland,Hermann Brenner,Hermann Brenner,Luigi Palmieri,Jean Dallongeville,Eric J. Brunner,Gerd Assmann,Maurizio Trevisan,Richard F. Gillum,Ian Ford,Naveed Sattar,Mariana Lazo,Simon G. Thompson,Pietro Ferrari,David A. Leon,George Davey Smith,Richard Peto,Rod Jackson,Emily Banks,Emanuele Di Angelantonio,John Danesh +132 more
TL;DR: Current drinkers of alcohol in high-income countries, the threshold for lowest risk of all-cause mortality was about 100 g/week, and data support limits for alcohol consumption that are lower than those recommended in most current guidelines.
Journal ArticleDOI
Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry.
Kornelia Kotseva,Kornelia Kotseva,Guy De Backer,Guy De Backer,Dirk De Bacquer,Dirk De Bacquer,Lars Rydén,Lars Rydén,Arno W. Hoes,Arno W. Hoes,Diederick E. Grobbee,Diederick E. Grobbee,Aldo P. Maggioni,Pedro Marques-Vidal,Pedro Marques-Vidal,Catriona Jennings,Catriona Jennings,Ana Abreu,Carlos Aguiar,J. Badariene,Jan Bruthans,Jan Bruthans,Almudena Castro Conde,Renata Cifkova,Renata Cifkova,J Crowley,J Crowley,Kairat Davletov,Jaap W. Deckers,Jaap W. Deckers,Delphine De Smedt,Delphine De Smedt,Johan De Sutter,Johan De Sutter,Mirza Dilic,Mirza Dilic,Marina Dolzhenko,Vilnis Dzerve,Vilnis Dzerve,Andrejs Erglis,Andrejs Erglis,Zlatko Fras,Zlatko Fras,Zlatko Fras,Dan Gaita,Nina Gotcheva,Peter U. Heuschmann,Hosam Hasan-Ali,Piotr Jankowski,Nebojsa Lalic,Seppo Lehto,Dragan Lovic,S. Mancas,Linda Mellbin,Linda Mellbin,Davor Milicic,Davor Milicic,Erkin M. Mirrakhimov,Erkin M. Mirrakhimov,Rafael G. Oganov,Nana Pogosova,Zeljko Reiner,Zeljko Reiner,S Stoerk,Lâle Tokgözoğlu,Lâle Tokgözoğlu,Costas Tsioufis,Costas Tsioufis,Dusko Vulic,David R. Wood,David R. Wood,David R. Wood +71 more
TL;DR: A large majority of coronary patients have unhealthy lifestyles in terms of smoking, diet and sedentary behaviour, which adversely impacts major cardiovascular risk factors, and a majority did not achieve their blood pressure, low-density lipoprotein cholesterol and glucose targets.
Journal ArticleDOI
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Amand F. Schmidt,Amand F. Schmidt,Michael V. Holmes,David Preiss,Daniel I. Swerdlow,Daniel I. Swerdlow,Spiros Denaxas,Spiros Denaxas,Ghazaleh Fatemifar,Rupert Faraway,Chris Finan,Dennis Valentine,Zammy Fairhurst-Hunter,Fernando Pires Hartwig,Bernardo L. Horta,Elina Hyppönen,Elina Hyppönen,Christine Power,Max Moldovan,Erik P A Van Iperen,Kees Hovingh,Ilja Demuth,Kristina Norman,Kristina Norman,Elisabeth Steinhagen-Thiessen,Juri Demuth,Lars Bertram,Lars Bertram,Christina M. Lill,Christina M. Lill,Stefan Coassin,Johann Willeit,Stefan Kiechl,Karin Willeit,Karin Willeit,Dan Mason,John Wright,Richard W Morris,Goya Wanamethee,Peter H. Whincup,Yoav Ben-Shlomo,Stela McLachlan,Jackie F. Price,Mika Kivimäki,Catherine Welch,Adelaida Sanchez-Galvez,Pedro Marques-Vidal,Andrew N. Nicolaides,Andrew N. Nicolaides,Andrie G. Panayiotou,N. Charlotte Onland-Moret,Yvonne T. van der Schouw,Giuseppe Matullo,Giovanni Fiorito,Simonetta Guarrera,Carlotta Sacerdote,Nicholas J. Wareham,Claudia Langenberg,Robert A. Scott,Jian'an Luan,Martin Bobak,Sofia Malyutina,Andrzej Pajak,Ruzena Kubinova,Abdonas Tamosiunas,Hynek Pikhart,Niels Grarup,Oluf Pedersen,Torben Hansen,Allan Linneberg,Tine Jess,Jackie A. Cooper,Steve E. Humphries,Murray H. Brilliant,Terrie Kitchner,Hakon Hakonarson,David Carrell,Catherine A. McCarty,Kirchner H. Lester,Eric B. Larson,David R. Crosslin,Mariza de Andrade,Dan M. Roden,Joshua C. Denny,Cara L. Carty,Stephen Hancock,John Attia,Elizabeth G. Holliday,Rodney J. Scott,Peter W. Schofield,Martin O'Donnell,Salim Yusuf,Michael Chong,Guillaume Paré,Pim van der Harst,Pim van der Harst,M. Abdullah Said,Ruben N. Eppinga,Niek Verweij,Harold Snieder,Tim Christen,Dennis O. Mook-Kanamori,Stefan Gustafsson,Lars Lind,Lars Lind,Erik Ingelsson,Erik Ingelsson,Raha Pazoki,Raha Pazoki,Oscar H. Franco,Albert Hofman,André G. Uitterlinden,Abbas Dehghan,Alexander Teumer,Sebastian E. Baumeister,Sebastian E. Baumeister,Marcus Dörr,Markus M. Lerch,Uwe Völker,Henry Völzke,Joey Ward,Jill P. Pell,Tom W. Meade,Ingrid E. Christophersen,Anke H. Maitland-van der Zee,Anke H. Maitland-van der Zee,Ekaterina V. Baranova,Robin Young,Ian Ford,Archie Campbell,Sandosh Padmanabhan,Michiel L. Bots,Diederick E. Grobbee,Philippe Froguel,Philippe Froguel,Dorothée Thuillier,Ronan Roussel,Amélie Bonnefond,Bertrand Cariou,Melissa C. Smart,Yanchun Bao,Meena Kumari,Anubha Mahajan,Jemma C. Hopewell,Sudha Seshadri,Caroline Dale,Rui Bebiano Da Providencia E Costa,Paul M. Ridker,Daniel I. Chasman,Alexander P. Reiner,Marylyn D. Ritchie,Leslie A. Lange,Alex J. Cornish,Sara E. Dobbins,Kari Hemminki,Ben Kinnersley,Marc Sanson,Karim Labreche,Matthias Simon,Melissa L. Bondy,Philip J. Law,Helen E. Speedy,James M. Allan,Ni Li,Molly Went,Niels Weinhold,Gareth J. Morgan,Pieter Sonneveld,Björn Nilsson,Hartmut Goldschmidt,Amit Sud,Andreas Engert,Markus Hansson,Harry Hemingway,Folkert W. Asselbergs,Folkert W. Asselbergs,Riyaz S. Patel,Riyaz S. Patel,Brendan J. Keating,Naveed Sattar,Richard S. Houlston,Juan P. Casas,Aroon D. Hingorani +182 more
TL;DR: Genetic variation at thePCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI, while indicating an increased risk of type 2 diabetes mellitus and no other possible safety concerns were shown.