Grace O. Silva

TL;DR: The ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity.

TL;DR: The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA with a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages.

TL;DR: The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels as mentioned in this paper.

TL;DR: Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis as mentioned in this paper, which has important implications for prognosis and therapeutic interventions.

TL;DR: An integrated genomic strategy based on the use of gene expression signatures of oncogenic pathway activity as a framework to analyze DNA copy number alterations in combination with data from a genome-wide RNA-mediated interference screen to identify therapeutic targets within amplicons through an integrated use of genomic data sets.