K
Ke Xu
Researcher at Yale University
Publications - 129
Citations - 9268
Ke Xu is an academic researcher from Yale University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 37, co-authored 103 publications receiving 8354 citations. Previous affiliations of Ke Xu include Veterans Health Administration & National Institutes of Health.
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Journal ArticleDOI
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Luda Diatchenko,Gary D. Slade,Andrea G. Nackley,Konakporn Bhalang,Asgeir Sigurdsson,Inna Belfer,David Goldman,Ke Xu,Svetlana A. Shabalina,Dmitry A. Shagin,Mitchell B. Max,Sergei S. Makarov,William Maixner +12 more
TL;DR: Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
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Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
Xian-Zhang Hu,Robert H. Lipsky,Guanshan Zhu,Longina A. Akhtar,Julie Taubman,Benjamin D. Greenberg,Ke Xu,Paul D. Arnold,Margaret A. Richter,James L. Kennedy,Dennis L. Murphy,David Goldman +11 more
TL;DR: The HTTLPR L(A)L( a) genotype exerts a moderate effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD.
Journal ArticleDOI
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
Jon Kar Zubieta,Mary M. Heitzeg,Yolanda R. Smith,Joshua A. Bueller,Ke Xu,Yanjun Xu,Robert A. Koeppe,Christian S. Stohler,David Goldman +8 more
TL;DR: Individuals homozygous for themet158 allele of the catechol-O-methyltransferase (COMT) polymorphism showed diminished regional μ-opioid system responses to pain compared with heterozygotes, and these effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state.
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Genetic variation in human NPY expression affects stress response and emotion
Zhifeng Zhou,Guanshan Zhu,Guanshan Zhu,Ahmad R. Hariri,Mary Anne Enoch,D. Scott,Rajita Sinha,Matti Virkkunen,Deborah C. Mash,Robert H. Lipsky,Xian Zhang Hu,Colin A. Hodgkinson,Ke Xu,Beata Buzas,Qiaoping Yuan,Pei Hong Shen,Robert E. Ferrell,Stephen B. Manuck,Sarah M. Brown,Richard L. Hauger,Christian S. Stohler,Jon Kar Zubieta,David Goldman +22 more
TL;DR: It is shown that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety, consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress.
Journal ArticleDOI
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament.
Hyungsuk Kim,John K. Neubert,Anitza San Miguel,Ke Xu,Raj K Krishnaraju,Michael J. Iadarola,David Goldman,Raymond A. Dionne +7 more
TL;DR: It is demonstrated that gender, ethnicity and temperament contribute to individual variation in thermal and cold pain sensitivity by interactions with TRPV1 and OPRD1 single nucleotide polymorphisms.