Journal ArticleDOI
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament.
Hyungsuk Kim,John K. Neubert,Anitza San Miguel,Ke Xu,Raj K Krishnaraju,Michael J. Iadarola,David Goldman,Raymond A. Dionne +7 more
Reads0
Chats0
TLDR
It is demonstrated that gender, ethnicity and temperament contribute to individual variation in thermal and cold pain sensitivity by interactions with TRPV1 and OPRD1 single nucleotide polymorphisms.Abstract:
While a variety of cultural, psychological and physiological factors contribute to variability in both clinical and experimental contexts, the role of genetic factors in human pain sensitivity is increasingly recognized as an important element. This study was performed to evaluate genetic influences on variability in human pain sensitivity associated with gender, ethnicity and temperament. Pain sensitivity in response to experimental painful thermal and cold stimuli was measured with visual analogue scale ratings and temperament dimensions of personality were evaluated. Loci in the vanilloid receptor subtype 1 gene (TRPV1), delta opioid receptor subtype 1 gene (OPRD1) and catechol O-methyltransferase gene (COMT) were genotyped using 5' nuclease assays. A total of 500 normal participants (306 females and 194 males) were evaluated. The sample composition was 62.0% European American, 17.4% African American, 9.0% Asian American, and 8.6% Hispanic, and 3.0% individuals with mixed racial parentage. Female European Americans with the TRPV1 Val(585) Val allele and males with low harm avoidance showed longer cold withdrawal times based on the classification and regression tree (CART) analysis. CART identified gender, an OPRD1 polymorphism and temperament dimensions of personality as the primary determinants of heat pain sensitivity at 49 degrees C. Our observations demonstrate that gender, ethnicity and temperament contribute to individual variation in thermal and cold pain sensitivity by interactions with TRPV1 and OPRD1 single nucleotide polymorphisms.read more
Citations
More filters
Journal ArticleDOI
Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings
Roger B. Fillingim,Christopher D. King,Margarete C. Ribeiro-Dasilva,B. Rahim-Williams,Joseph L. Riley +4 more
TL;DR: Current human findings regarding sex differences in experimental pain indicate greater pain sensitivity among females compared with males for most pain modalities, including more recently implemented clinically relevant pain models such as temporal summation of pain and intramuscular injection of algesic substances.
Journal ArticleDOI
A comprehensive review of opioid-induced hyperalgesia.
TL;DR: Clinicians should suspect OIH when opioid treatment's effect seems to wane in the absence of disease progression, particularly if found in the context of unexplained pain reports or diffuse allodynia unassociated with the original pain, and increased levels of pain with increasing dosages.
Journal ArticleDOI
Racial and ethnic disparities in pain: causes and consequences of unequal care.
TL;DR: This review reveals the persistence of racial and ethnic disparities in acute, chronic, cancer, and palliative pain care across the lifespan and treatment settings, with minorities receiving lesser quality pain care than non-Hispanic whites.
Journal ArticleDOI
A systematic literature review of 10 years of research on sex/gender and experimental pain perception - part 1: are there really differences between women and men?
Mélanie Racine,Yannick Tousignant-Laflamme,Lorie A. Kloda,Dominique Dion,Gilles Dupuis,Gilles Dupuis,Manon Choinière +6 more
TL;DR: 10 years of laboratory research have not been successful in producing a clear and consistent pattern of sex differences in human pain sensitivity, even with the use of deep, tonic, long‐lasting stimuli, which are known to better mimic clinical pain.
Journal ArticleDOI
Pain and stress in a systems perspective: reciprocal neural, endocrine, and immune interactions.
TL;DR: A psychophysiological systems view of pain in which physical injury, or wounding, generates a complex stress response that extends beyond the nervous system and contributes to the experience of pain is advanced.
References
More filters
Journal ArticleDOI
Classification and Regression Trees.
Journal ArticleDOI
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Michael J. Caterina,Mark Schumacher,Makoto Tominaga,Tobias A. Rosen,Jon D. Levine,David Julius +5 more
TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Journal ArticleDOI
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
Michael J. Caterina,A. Leffler,Annika B. Malmberg,William J. Martin,Jodie A. Trafton,K. R. Petersen-Zeitz,Martin Koltzenburg,Allan I. Basbaum,David Julius +8 more
TL;DR: Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.
Journal ArticleDOI
Classification and regression trees: a powerful yet simple technique for ecological data analysis
TL;DR: This work uses classification and regression trees to analyze survey data from the Australian central Great Barrier Reef, comprising abundances of soft coral taxa and physical and spatial environmental information and shows how linear models fail to find patterns uncovered by the trees.
Journal ArticleDOI
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
TL;DR: These findings, together with the previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.
Related Papers (5)
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
Irmgard Tegeder,Michael Costigan,Robert S. Griffin,Andrea Abele,Inna Belfer,Helmut Schmidt,Corina Ehnert,Jemiel Nejim,Jemiel Nejim,Claudiu Marian,Joachim Scholz,Tianxia Wu,Andrew Allchorne,Luda Diatchenko,Alexander M. Binshtok,David Goldman,Jan Adolph,Swetha Sama,Steven J. Atlas,William A. Carlezon,Aram Parsegian,Jörn Lötsch,Roger B. Fillingim,William Maixner,Gerd Geisslinger,Mitchell B. Max,Clifford J. Woolf +26 more
The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
Jeffrey S. Mogil,Sonya G. Wilson,Elissa J. Chesler,Andrew L. Rankin,Kumar V.S. Nemmani,William R. Lariviere,M. Kristina Groce,Margaret R. Wallace,Lee M. Kaplan,Roland Staud,Timothy J. Ness,Toni L. Glover,Magda Stankova,Alexander V. Mayorov,Victor J. Hruby,Judith E. Grisel,Roger B. Fillingim +16 more