Showing papers by "Mariana F. Fernández published in 2021"
University of Padua1, University of Lausanne2, Universidade Nova de Lisboa3, Technical University of Dortmund4, Mario Negri Institute for Pharmacological Research5, Institut national de la recherche scientifique6, Flemish Institute for Technological Research7, Istituto Superiore di Sanità8, University College Dublin9, Karolinska Institutet10, University of Rennes11, University of Granada12, Instituto Nacional de Saúde Dr. Ricardo Jorge13
TL;DR: An overview of available effect biomarkers for monitoring chemical exposures in the general and occupational populations, and highlight their potential in monitoring humans exposed to chemical mixtures is provided.
38 citations
TL;DR: In this article, a systematic literature review based on PubMed entries published before July 2019 that addressed Pb exposure and biomarkers of effect and susceptibility, neurodevelopmental toxicity, epigenetic modifications, and transcriptomics was conducted.
32 citations
Emory University1, Pompeu Fabra University2, University of Grenoble3, Harvard University4, University of California, Berkeley5, Andalusian School of Public Health6, Deakin University7, University of Melbourne8, Icahn School of Medicine at Mount Sinai9, Dartmouth College10, Basque Government11, University of the Basque Country12, University of Paris13, Université de Sherbrooke14, University of Valencia15, University of Granada16, University of Oviedo17, National Institutes of Health18
TL;DR: A meta-analysis of the associations between smoking during pregnancy and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium is presented in this article.
Abstract: Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.
26 citations
TL;DR: In this article, the authors developed a new and practical method for determining three bisphenols, four parabens, and five benzophenones in placenta samples using dispersive liquid-liquid microextraction (DLLME) in combination with gas chromatography-tandem mass spectrometry (GC-MS/MS).
26 citations
TL;DR: In this paper, the in vitro effects of BPS and BPF on the adipogenesis of human adipose-derived stem cells (hASCs) exposed to different doses (0.01, 0.1, 1, 10 and 25μM), stopping the adipogenic process at 7 or 14 days.
24 citations
TL;DR: Serrano et al. as discussed by the authors developed a PhD thesis in the context of the "Clinical Medicine and Public Health Program" of the University of Granada, which was funded in part by grants from the European Human Biomonitoring Initiative H2020-EJP-HBM4EU, Biomedical Research Networking Center-CIBER de Epidemiologia y Salud Publica, and the Carlos III Institute of Health.
24 citations
TL;DR: The state-of-the-art on the use of receptor-based in vitro assays for mixture toxicity assessment on human samples and effect-directed analysis (EDA) using high resolution mass spectrometry (HRMS) for identification of toxic compounds waits for exploration.
23 citations
TL;DR: In this paper, the relationship between urinary pesticide metabolites and altered thyroid and reproductive hormones were observed. But the associations observed between urinary pesticides metabolites were novel and should be verified in studies with larger sample size.
22 citations
TL;DR: In this paper, the authors identified effect biomarkers linking hexavalent chromium and cadmium exposure to selected adverse outcomes (AOs) including cancer, immunotoxicity, oxidative stress, and omics/epigenetics.
20 citations
TL;DR: In this article, the association between urinary metabolites of organophosphate (OP) pesticides and serum concentrations of thyroid and reproductive hormones in male adolescents and to assess the potential effect of interactions between OP pesticides and paraoxonase 1 (PON1) polymorphisms on hormone levels.
17 citations
TL;DR: In this paper, a systematic search was performed from open literature and ToxCast/Tox21 programs, and results from in vitro tests on the activities of 52 replacement flame retardants towards five hormone nuclear receptors (NRs) associated with reproductive outcomes (estrogen, androgen, glucocorticoid, progesterone, and aryl hydrocarbon receptors) were compiled and organized into tables.
University of Lisbon1, Technical University of Denmark2, University of Lausanne3, Flemish Institute for Technological Research4, Universidade Nova de Lisboa5, University of Granada6, European Environment Agency7, Health Canada8, National Institute for Environmental Studies9, Finnish Institute of Occupational Health10, University of Paris11, Wageningen University and Research Centre12, Health and Safety Executive13, Instituto Nacional de Saúde Dr. Ricardo Jorge14, Katholieke Universiteit Leuven15, University of Padua16, Environment Agency17
TL;DR: The HBM Global Registry Framework (HBM GRF) as mentioned in this paper is a host-independent HBM registry framework based on the use of harmonised open-access protocol templates from designing, undertaking of an HBM study to the use and possible reuse of the resulting HBM (meta)data.
Duke University1, Norwegian University of Science and Technology2, University of Illinois at Chicago3, Boston University4, University of Turin5, Health Canada6, Southern Illinois University School of Medicine7, Brunel University London8, National Institutes of Health9, Indiana University10, University of Granada11
TL;DR: In this article, the authors evaluated reproducibility across laboratories, assess factors that might contribute to varying degrees of differentiation between laboratories (media additives, plastics, cell source, etc.), or to standardize protocols.
TL;DR: In this article, the authors presented RL, which was partially funded by PID2019-107036RB-I00, from Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain, and PID2020-0287, from IIS ISABIAL, Hospital General Universitario, Alicante, Spain.
Abstract: This study has been partially funded by PID2019-107036RB-I00, from Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain, and 2020-0287, from IIS ISABIAL, Hospital General Universitario, Alicante, Spain. RL is recipient of a grant (FPU 18/00063) by Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain.
TL;DR: In this article, retinol levels were measured in both serum and adipose tissue along with RBP4 levels in serum samples of 236 participants of the GraMo adult cohort, and associations were explored by multivariable linear regression analyses and Weighted Quantile Sum regression.
TL;DR: In this paper, the combined biological activity of chemical mixtures extracted from human placentas using one in vivo and four in vitro bioassays, also known as biomarkers of combined effect, was examined.
TL;DR: In this paper, the association between urinary BPA concentrations and human sperm DNA fragmentation (SDF) was investigated with 158 healthy university students (18-23 years), recruited between 2010 and 2011 in the Region of Murcia (Spain).
TL;DR: In this paper, the authors explore clusters of a mixture of 15 persistent toxic substances (PTSs) in the adipose tissue of 227 individuals of an adult cohort from Granada Province (Spain).