M
Michael Hughes
Researcher at Royal Hallamshire Hospital
Publications - 615
Citations - 26328
Michael Hughes is an academic researcher from Royal Hallamshire Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 74, co-authored 531 publications receiving 24066 citations. Previous affiliations of Michael Hughes include Royal College of Physicians & St Thomas' Hospital.
Papers
More filters
Journal ArticleDOI
A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less
Scott M. Hammer,Kathleen Squires,Michael Hughes,Michael Hughes,Janet M. Grimes,Lisa M. Demeter,Judith S. Currier,Joseph J. Eron,Judith Feinberg,Henry H. Balfour,Lawrence Deyton,Chodakewitz Jeffrey A,Margaret A. Fischl,John P. Phair,William Spreen,Louise Pedneault,Bach-Yen Nguyen,Jon C. Cook +17 more
TL;DR: In this article, the efficacy and safety of adding a protease inhibitor to two nucleoside analogues to treat human immunodeficiency virus type 1 (HIV-1) infection are not clear.
Journal ArticleDOI
A Trial Comparing Nucleoside Monotherapy with Combination Therapy in HIV-Infected Adults with CD4 Cell Counts from 200 to 500 per Cubic Millimeter
Scott M. Hammer,David Katzenstein,Michael Hughes,Holly Gundacker,Robert T. Schooley,Richard Haubrich,W. Keith Henry,Michael M. Lederman,John P. Phair,Manette T. Niu,Martin S. Hirsch,Thomas C. Merigan +11 more
TL;DR: In this article, a double-blind study evaluated treatment with either a single nucleoside or two nucleosides in adults infected with human immunodeficiency virus type 1 (HIV-1) whose CD4 cell counts were from 200 to 500 per cubic millimeter.
Journal ArticleDOI
Antithrombotic Therapy for Atrial Fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
John J. You,Daniel E. Singer,Patricia A. Howard,Deirdre A. Lane,Mark H. Eckman,Margaret C. Fang,Elaine M. Hylek,Sam Schulman,Alan S. Go,Michael Hughes,Frederick A. Spencer,Warren J. Manning,Jonathan L. Halperin,Gregory Y.H. Lip +13 more
TL;DR: Oral anticoagulation is the optimal choice of antithrombotic therapy for patients with AF at high risk of stroke (CHADS(2) score of ≥ 2) and at lower levels of stroke risk, antithROMbotic treatment decisions will require a more individualized approach.
Journal ArticleDOI
Extensive Diversity of Ig-Superfamily Proteins in the Immune System of Insects
Fiona L. Watson,Roland Püttmann-Holgado,Franziska Thomas,David L. Lamar,Michael Hughes,Masahiro Kondo,Vivienne I. Rebel,Dietmar Schmucker +7 more
TL;DR: Evidence is presented that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin-superfamily receptor Down syndrome cell adhesion molecule (Dscam), and the molecular diversity of Dscam transcripts generated through a mechanism of alternative splicing is highly conserved across major insect orders, suggesting an unsuspected molecular complexity of the innate immune system of insects.
Journal ArticleDOI
Statistical problems in the reporting of clinical trials. A survey of three medical journals.
TL;DR: Overall, the reporting of clinical trials appears to be biased toward an exaggeration of treatment differences, and more emphasis should be given to the magnitude of treatment Differences and to estimation methods such as confidence intervals.