N
Nicholas B. Larson
Researcher at Mayo Clinic
Publications - 140
Citations - 2554
Nicholas B. Larson is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 19, co-authored 81 publications receiving 1519 citations. Previous affiliations of Nicholas B. Larson include University of Minnesota & Baylor College of Medicine.
Papers
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Journal ArticleDOI
From genome-wide associations to candidate causal variants by statistical fine-mapping.
TL;DR: The strengths and weaknesses of different fine-mapping approaches are reviewed, emphasizing the main factors that affect performance, including integration of trans-ethnic human population data and functional annotations.
Journal ArticleDOI
Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19
Junjie Tony Hua,Junjie Tony Hua,Musaddeque Ahmed,Haiyang Guo,Yuzhe Zhang,Yuzhe Zhang,Yuzhe Zhang,Sujun Chen,Sujun Chen,Fraser Soares,Jennifer Q. Lu,Jennifer Q. Lu,Stanley Zhou,Stanley Zhou,Miranda Wang,Hui Li,Nicholas B. Larson,Shannon K. McDonnell,Parasvi S. Patel,Parasvi S. Patel,Yi Liang,Cindy Q. Yao,Theodorus van der Kwast,Mathieu Lupien,Mathieu Lupien,Mathieu Lupien,Felix Y. Feng,Amina Zoubeidi,Ming-Sound Tsao,Ming-Sound Tsao,Stephen N. Thibodeau,Paul C. Boutros,Paul C. Boutros,Housheng Hansen He,Housheng Hansen He +34 more
TL;DR: Findings reveal a risk SNP-mediated promoter-enhancer switching mechanism underlying both initiation and progression of aggressive PCa.
Journal ArticleDOI
Complementation contributes to transcriptome complexity in maize (Zea mays L.) hybrids relative to their inbred parents
Anja Paschold,Yi Jia,Caroline Marcon,Steve Lund,Nicholas B. Larson,Cheng Ting Yeh,Stephan Ossowski,Christa Lanz,Dan Nettleton,Patrick S. Schnable,Frank Hochholdinger +10 more
TL;DR: In hybrids, ∼14% of expressed genes exhibited allele-specific expression (ASE) levels that differed significantly from the parental-inbred expression ratios, providing further evidence for interactions of regulatory factors from one parental genome with target genes from the other parental genome.
Journal ArticleDOI
Clinical Characteristics of Ovarian Cancer Classified by BRCA1, BRCA2, and RAD51C Status
Julie M. Cunningham,Mine S. Cicek,Nicholas B. Larson,Jaime I. Davila,Chen Wang,Melissa C. Larson,Honglin Song,Ed Dicks,Patricia Harrington,Myra J. Wick,Boris Winterhoff,Habib Hamidi,Gottfried E. Konecny,Jeremy Chien,Marina Bibikova,Jian-Bing Fan,Kimberly R. Kalli,Noralane M. Lindor,Brooke L. Fridley,P Pharoah,Ellen L. Goode +20 more
TL;DR: HRD patients with germline or somatic alterations in any gene were more likely to be high grade serous, have an earlier diagnosis age and have ovarian and/or breast cancer family history, and Identification of EOC patients with an HRD phenotype may help tailor specific therapies.
Journal ArticleDOI
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Aldi T. Kraja,Chunyu Liu,Jessica L. Fetterman,Mariaelisa Graff,Christian Theil Have,Charles Gu,Lisa R. Yanek,Mary F. Feitosa,Dan E. Arking,Daniel I. Chasman,Kristin L. Young,Symen Ligthart,W. David Hill,Stefan Weiss,Jian'an Luan,Franco Giulianini,Ruifang Li-Gao,Fernando Pires Hartwig,Fernando Pires Hartwig,Shiow J. Lin,Lihua Wang,Tom G. Richardson,Jie Yao,Eliana Portilla Fernández,Mohsen Ghanbari,Mary K. Wojczynski,Wen Jane Lee,Maria Argos,Sebastian M. Armasu,Ruteja A. Barve,Kathleen A. Ryan,Ping An,Thomas J. Baranski,Suzette J. Bielinski,Donald W. Bowden,Ulrich Broeckel,Kaare Christensen,Audrey Y. Chu,Janie Corley,Simon R. Cox,André G. Uitterlinden,Fernando Rivadeneira,Cheryl D. Cropp,E. Warwick Daw,Diana van Heemst,Lisa de las Fuentes,He Gao,Ioanna Tzoulaki,Ioanna Tzoulaki,Tarunveer S. Ahluwalia,Renée de Mutsert,Leslie S. Emery,A. Mesut Erzurumluoglu,James A. Perry,Mao Fu,Nita G. Forouhi,Zhenglong Gu,Yang Hai,Sarah E. Harris,Gibran Hemani,Steven C. Hunt,Marguerite R. Irvin,Anna Jonsson,Anne E. Justice,Nicola D. Kerrison,Nicholas B. Larson,Keng Hung Lin,Latisha Love-Gregory,Rasika A. Mathias,Joseph H. Lee,Matthias Nauck,Raymond Noordam,Ken K. Ong,James S. Pankow,Amit Patki,Alison Pattie,Astrid Petersmann,Qibin Qi,Rasmus Ribel-Madsen,Rebecca Rohde,Kevin Sandow,Theresia M. Schnurr,Tamar Sofer,Tamar Sofer,John M. Starr,Adele M. Taylor,Alexander Teumer,Nicholas J. Timpson,Hugoline G. de Haan,Yujie Wang,Peter Weeke,Christine Williams,Hongsheng Wu,Wei Yang,Donglin Zeng,Daniel R. Witte,Bruce S. Weir,Nicholas J. Wareham,Henrik Vestergaard,Henrik Vestergaard,Stephen Turner,Christian Torp-Pedersen,Evie Stergiakouli,Wayne Huey-Herng Sheu,Frits R. Rosendaal,M. Arfan Ikram,Oscar H. Franco,Oscar H. Franco,Paul M. Ridker,Thomas T. Perls,Oluf Pedersen,Ellen A. Nohr,Anne B. Newman,Allan Linneberg,Claudia Langenberg,Tuomas O. Kilpeläinen,Sharon L.R. Kardia,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Thorkild I. A. Sørensen,Georg Homuth,Torben Hansen,Mark O. Goodarzi,Ian J. Deary,Cramer Christensen,Yii-Der Ida Chen,Aravinda Chakravarti,Ivan Brandslund,Klaus Bønnelykke,Kent D. Taylor,James G. Wilson,Santiago Rodriguez,Gail Davies,Bernardo L. Horta,Bharat Thyagarajan,Dabeeru C. Rao,Niels Grarup,Victor G. Davila-Roman,Gavin Hudson,Xiuqing Guo,Donna K. Arnett,Caroline Hayward,Dhananjay Vaidya,Dennis O. Mook-Kanamori,Hemant K. Tiwari,Daniel Levy,Ruth J. F. Loos,Abbas Dehghan,Paul Elliott,Afshan N. Malik,Robert A. Scott,Diane M. Becker,Mariza de Andrade,Michael A. Province,James B. Meigs,James B. Meigs,Jerome I. Rotter,Kari E. North +158 more
TL;DR: The results suggest that mtDNA and MT-nDNA genes and variants reported make important contributions to glucose and insulin metabolism, adipocyte regulation, diabetes, and cardiovascular disease.