O
Olivier B. Bakker
Researcher at University Medical Center Groningen
Publications - 21
Citations - 497
Olivier B. Bakker is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 7, co-authored 18 publications receiving 183 citations.
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Journal ArticleDOI
Genetic insights into biological mechanisms governing human ovarian ageing.
Katherine S. Ruth,Felix R. Day,Jazib Hussain,Ana Martínez-Marchal,Catherine E. Aiken,Ajuna Azad,Deborah J. Thompson,Lucie Knoblochova,Lucie Knoblochova,Hironori Abe,Jane L. Tarry-Adkins,Javier Martin Gonzalez,Pierre Fontanillas,Annique Claringbould,Olivier B. Bakker,Patrick Sulem,Robin G. Walters,Chikashi Terao,Sandra Turon,Momoko Horikoshi,Kuang Lin,N. Charlotte Onland-Moret,Aditya Sankar,Emil Peter Thrane Hertz,Pascal Timshel,Vallari Shukla,Rehannah Borup,Kristina W. Olsen,Kristina W. Olsen,Paula Aguilera,Paula Aguilera,Mònica Ferrer-Roda,Yan Huang,Stasa Stankovic,Paul R. H. J. Timmers,Paul R. H. J. Timmers,Thomas U. Ahearn,Behrooz Z. Alizadeh,Elnaz Naderi,Irene L. Andrulis,Irene L. Andrulis,Alice M. Arnold,Kristan J. Aronson,Annelie Augustinsson,Stefania Bandinelli,Caterina Barbieri,Robin N Beaumont,Heiko Becher,Matthias W. Beckmann,Stefania Benonisdottir,Sven Bergmann,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Stig E. Bojesen,Stig E. Bojesen,Manjeet K. Bolla,Dorret I. Boomsma,Dorret I. Boomsma,Nicholas Bowker,Jennifer A. Brody,Linda Broer,Julie E. Buring,Julie E. Buring,Archie Campbell,Harry Campbell,Jose E. Castelao,Eulalia Catamo,Stephen J. Chanock,Georgia Chenevix-Trench,Marina Ciullo,Tanguy Corre,Tanguy Corre,Fergus J. Couch,Angela Cox,Laura Crisponi,Simon S. Cross,Francesco Cucca,Francesco Cucca,Kamila Czene,George Davey Smith,Eco J. C. de Geus,Eco J. C. de Geus,Renée de Mutsert,Immaculata De Vivo,Immaculata De Vivo,Ellen W. Demerath,Joe Dennis,Alison M. Dunning,Miriam Dwek,Mikael Eriksson,Tõnu Esko,Tõnu Esko,Peter A. Fasching,Peter A. Fasching,Jessica D. Faul,Luigi Ferrucci,Nora Franceschini,Timothy M. Frayling,Manuela Gago-Dominguez,Massimo Mezzavilla,Montserrat Garcia-Closas,Christian Gieger,Graham G. Giles,Graham G. Giles,Graham G. Giles,Harald Grallert,Daniel F. Gudbjartsson,Vilmundur Gudnason,Pascal Guénel,Christopher A. Haiman,Niclas Håkansson,Per Hall,Caroline Hayward,Chunyan He,Wei He,Gerardo Heiss,Miya Kudo Høffding,John L. Hopper,Jouke J. Hottenga,Jouke J. Hottenga,Frank B. Hu,Frank B. Hu,David G. Hunter,Mohammad Arfan Ikram,Rebecca D. Jackson,Micaella Joaquim,Esther M. John,Peter K. Joshi,David Karasik,Sharon L.R. Kardia,Christiana Kartsonaki,Robert Karlsson,Cari M. Kitahara,Ivana Kolcic,Charles Kooperberg,Peter Kraft,Allison W. Kurian,Zoltán Kutalik,Zoltán Kutalik,Martina La Bianca,Genevieve Lachance,Claudia Langenberg,Lenore J. Launer,Joop S.E. Laven,Debbie A Lawlor,Loic Le Marchand,Jingmei Li,Annika Lindblom,Annika Lindblom,Sara Lindström,Tricia Lindstrom,Martha S. Linet,Yongmei Liu,Simin Liu,Jian'an Luan,Reedik Mägi,Patrik K. E. Magnusson,Massimo Mangino,Massimo Mangino,Arto Mannermaa,Brumat Marco,Jonathan Marten,Nicholas G. Martin,Hamdi Mbarek,Hamdi Mbarek,Barbara McKnight,Sarah E. Medland,Christa Meisinger,Thomas Meitinger,Cristina Menni,Andres Metspalu,Lili Milani,Roger L. Milne,Roger L. Milne,Roger L. Milne,Grant W. Montgomery,Dennis O. Mook-Kanamori,Antonella Mulas,Anna Marie Mulligan,Anna Marie Mulligan,Alison D. Murray,Mike A. Nalls,Anne B. Newman,Raymond Noordam,Teresa Nutile,Dale R. Nyholt,Andrew F. Olshan,Håkan Olsson,Jodie N. Painter,Alpa V. Patel,Nancy L. Pedersen,Natalia Perjakova,Annette Peters,Ulrike Peters,Paul D.P. Pharoah,Ozren Polasek,Eleonora Porcu,Bruce M. Psaty,Iffat Rahman,Gad Rennert,Hedy S. Rennert,Paul M. Ridker,Paul M. Ridker,Susan M. Ring,Antonietta Robino,Lynda M. Rose,Frits R. Rosendaal,Jacques E. Rossouw,Igor Rudan,Rico Rueedi,Rico Rueedi,Daniela Ruggiero,Cinzia Sala,Emmanouil Saloustros,Dale P. Sandler,Serena Sanna,Elinor J. Sawyer,Chloé Sarnowski,David Schlessinger,Marjanka K. Schmidt,Minouk J. Schoemaker,Katharina E. Schraut,Katharina E. Schraut,Christopher G. Scott,Saleh Shekari,Amruta Shrikhande,Albert V. Smith,Blair H. Smith,Jennifer A. Smith,Rossella Sorice,Melissa C. Southey,Melissa C. Southey,Melissa C. Southey,Tim D. Spector,John J. Spinelli,Meir J. Stampfer,Meir J. Stampfer,Doris Stöckl,Joyce B. J. van Meurs,Konstantin Strauch,Konstantin Strauch,Unnur Styrkarsdottir,Anthony J. Swerdlow,Toshiko Tanaka,Lauren R. Teras,Alexander Teumer,Unnur Þorsteinsdottir,Unnur Þorsteinsdottir,Nicholas J. Timpson,Daniela Toniolo,Michela Traglia,Melissa A. Troester,Thérèse Truong,Jessica Tyrrell,André G. Uitterlinden,Sheila Ulivi,Celine M. Vachon,Veronique Vitart,Uwe Völker,Peter Vollenweider,Henry Völzke,Qin Wang,Nicholas J. Wareham,Clarice R. Weinberg,David R. Weir,Amber N. Wilcox,Ko Willems van Dijk,Gonneke Willemsen,Gonneke Willemsen,James F. Wilson,James F. Wilson,Bruce H. R. Wolffenbuttel,Alicja Wolk,Alicja Wolk,Andrew R. Wood,Wei Zhao,Marek Zygmunt,Zhengming Chen,Liming Li,Lude Franke,Stephen Burgess,Patrick Deelen,Patrick Deelen,Tune H. Pers,Marie Louise Grøndahl,Claus Yding Andersen,Anna Pujol,Andrés J. López-Contreras,Andrés J. López-Contreras,Jeremy A. Daniel,Kari Stefansson,Kari Stefansson,Jenny Chang-Claude,Jenny Chang-Claude,Yvonne T. van der Schouw,Kathryn L. Lunetta,Daniel I. Chasman,Daniel I. Chasman,Douglas F. Easton,Jenny A. Visser,Susan E. Ozanne,Satoshi H. Namekawa,Petr Solc,Joanne M. Murabito,Ken K. Ong,Eva Hoffmann,Anna Murray,Ignasi Roig,John R. B. Perry,John R. B. Perry +310 more
TL;DR: In this paper, the authors identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in about 200,000 women of European ancestry.
Journal ArticleDOI
Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses
Olivier B. Bakker,Raul Aguirre-Gamboa,Serena Sanna,Marije Oosting,Sanne P. Smeekens,Martin Jaeger,Maria M. Zorro,Urmo Võsa,Sebo Withoff,Romana T. Netea-Maier,Hans J. P. M. Koenen,Irma Joosten,Ramnik J. Xavier,Lude Franke,Leo A. B. Joosten,Vinod Kumar,Vinod Kumar,Cisca Wijmenga,Cisca Wijmenga,Mihai G. Netea,Mihai G. Netea,Yang Li +21 more
TL;DR: It is shown that integration of multi-omics data and deep phenotyping enables prediction of cytokine production in responses to pathogens, and a computational model based on genetic data predicted the genetic component of stimulus-induced cytokineProduction and nongenetic factors influenced cytokineproduction.
Journal ArticleDOI
A practical view of fine-mapping and gene prioritization in the post-genome-wide association era
TL;DR: The combination of fine-mapping and gene prioritization by statistical, functional and population-based strategies will be necessary to truly understand how GWAS loci contribute to complex traits and diseases.
Journal ArticleDOI
Deconvolution of bulk blood eQTL effects into immune cell subpopulations
Raul Aguirre-Gamboa,Niek de Klein,Jennifer di Tommaso,Annique Claringbould,Monique G. P. van der Wijst,Dylan H. de Vries,Harm Brugge,Roy Oelen,Urmo Võsa,Urmo Võsa,Maria M. Zorro,Xiaojin Chu,Xiaojin Chu,Olivier B. Bakker,Zuzanna Borek,Isis Ricaño-Ponce,Patrick Deelen,Cheng-Jian Xu,Cheng-Jian Xu,Morris A. Swertz,Iris Jonkers,Sebo Withoff,Irma Joosten,Serena Sanna,Vinod Kumar,Vinod Kumar,Hans J. P. M. Koenen,Leo A. B. Joosten,Mihai G. Netea,Mihai G. Netea,Cisca Wijmenga,Lude Franke,Yang Li,Yang Li,Yang Li +34 more
TL;DR: Decon2 provides a method to detect cell type interaction effects from bulk blood eQTLs that is useful for pinpointing the most relevant cell type for a given complex disease.
Journal ArticleDOI
Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort.
Katherine Mc Intyre,Pauline Lanting,Patrick Deelen,Patrick Deelen,Henry Wiersma,Judith M. Vonk,Anil P.S. Ori,Soesma A Jankipersadsing,Robert Warmerdam,Irene V. van Blokland,Floranne Boulogne,Marjolein X.L. Dijkema,Johanna C. Herkert,Annique Claringbould,Olivier B. Bakker,Esteban A Lopera Maya,Ute Bültmann,Alexandra Zhernakova,Sijmen A. Reijneveld,Elianne Zijlstra,Morris A. Swertz,Sandra Brouwer,Raun van Ooijen,Viola Angelini,Louise H. Dekker,Louise H. Dekker,Anna Sijtsma,Sicco A. Scherjon,Cisca Wijmenga,Jackie A M Dekens,Jochen O. Mierau,H. Marike Boezen,Lude Franke +32 more
TL;DR: The Lifelines COVID-19 cohort as discussed by the authors was set up to assess the psychological and societal impacts of the COVID19 pandemic and investigate potential risk factors within the Lifelines prospective population cohort.