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Hedy S. Rennert

Researcher at Technion – Israel Institute of Technology

Publications -  106
Citations -  6078

Hedy S. Rennert is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Population & Cancer. The author has an hindex of 35, co-authored 101 publications receiving 4385 citations. Previous affiliations of Hedy S. Rennert include Rappaport Faculty of Medicine & Clalit Health Services.

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Association analysis identifies 65 new breast cancer risk loci

Kyriaki Michailidou, +396 more
- 02 Nov 2017 - 
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
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Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Nasim Mavaddat, +310 more
- 03 Jan 2019 - 
TL;DR: This PRS, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset is developed and empirically validated and is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.
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Discovery of common and rare genetic risk variants for colorectal cancer

Jeroen R. Huyghe, +224 more
- 01 Jan 2019 - 
TL;DR: Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.
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Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations.

Gad Rennert, +6 more
- 12 Jul 2007 - 
TL;DR: Breast cancer-specific rates of death among Israeli women are similar for carriers of a BRCA founder mutation and noncarriers.
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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

Roger L. Milne, +512 more
- 23 Oct 2017 - 
TL;DR: A genome-wide association study (GWAS) of predominantly estrogen receptor (ER)-positive disease and BRCA1 mutation carrier GWAS observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies, which explain approximately 16% of the familial risk of this breast cancer subtype.