P
Paul J. van Diest
Researcher at Utrecht University
Publications - 514
Citations - 22750
Paul J. van Diest is an academic researcher from Utrecht University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 70, co-authored 459 publications receiving 18892 citations. Previous affiliations of Paul J. van Diest include University Medical Center Utrecht & VU University Medical Center.
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Journal ArticleDOI
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity
Norman Sachs,Joep de Ligt,Oded Kopper,Ewa Gogola,Gergana Bounova,Fleur Weeber,Anjali Vanita Balgobind,Karin Wind,Ana Gracanin,Harry Begthel,Jeroen Korving,Ruben van Boxtel,Alexandra A. Duarte,Daphne Lelieveld,Arne Van Hoeck,Robert F Ernst,Francis Blokzijl,Isaac J. Nijman,Marlous Hoogstraat,Marieke van der Ven,David A. Egan,Vittoria Zinzalla,Jürgen Moll,Sylvia F. Boj,Emile E. Voest,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Paul J. van Diest,Sven Rottenberg,Sven Rottenberg,Robert G.J. Vries,Edwin Cuppen,Hans Clevers +32 more
TL;DR: This study describes a representative collection of well-characterized BC organoids available for cancer research and drug development, as well as a strategy to assess in vitro drug response in a personalized fashion.
Journal ArticleDOI
Levels of Hypoxia-Inducible Factor-1α During Breast Carcinogenesis
Reinhard Bos,Hua Zhong,Colleen F. Hanrahan,Ellen C. M. Mommers,Gregg L. Semenza,Herbert M. Pinedo,Martin D. Abeloff,Jonathan W. Simons,Paul J. van Diest,Elsken van der Wall +9 more
TL;DR: In this paper, the authors investigated whether the level of HIF-1α is increased during carcinogenesis in breast tissue and is associated with other tumor biomarkers, such as vascular endothelial growth factor (VEGF), HER-2/neu, p53, Ki-67, and estrogen receptor (ER).
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Breast Cancer Histopathology Image Analysis: A Review
TL;DR: This paper presents an overview of methods that have been proposed for the analysis of breast cancer histopathology images, and a discussion of the different image processing techniques and applications, ranging from analysis of tissue staining to computer-aided diagnosis, and prognosis of Breast cancer patients.
Journal ArticleDOI
Micrometastases or Isolated Tumor Cells and the Outcome of Breast Cancer
Maaike de Boer,Carolien H.M. van Deurzen,Jos A.A.M. van Dijck,George F. Borm,Paul J. van Diest,Eddy M. M. Adang,Johan W.R. Nortier,Emiel J. Th. Rutgers,Caroline Seynaeve,Marian B. E. Menke-Pluymers,Peter Bult,Vivianne C. G. Tjan-Heijnen +11 more
TL;DR: Isolated tumor cells or micrometastases in regional lymph nodes were associated with a reduced 5-year rate of disease-free survival among women with favorable early-stage breast cancer who did not receive adjuvant therapy.
Journal ArticleDOI
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
Oded Kopper,Chris J. de Witte,Kadi Lõhmussaar,Jose Espejo Valle-Inclan,Nizar Hami,Lennart Kester,Anjali Vanita Balgobind,Jeroen Korving,Natalie Proost,Harry Begthel,Lise M van Wijk,Sonia Aristín Revilla,Rebecca Theeuwsen,Marieke van de Ven,Markus J. van Roosmalen,Bas Ponsioen,Victor W.H. Ho,Benjamin G. Neel,Tjalling Bosse,Katja N. Gaarenstroom,Harry Vrieling,Maaike P.G. Vreeswijk,Paul J. van Diest,Petronella O. Witteveen,Trudy N. Jonges,Johannes L. Bos,Alexander van Oudenaarden,Ronald P. Zweemer,Hugo J. Snippert,Wigard P. Kloosterman,Hans Clevers +30 more
TL;DR: A biobank of ovarian cancer organoids recapitulates the histopathological and molecular hallmarks of patient tumors and provides a resource for preclinical research and demonstrates their potential application for research and personalized medicine.