Peter J. Barnes

TL;DR: Autoradiographic methods were used to determine the distribution of autonomic receptors in airway smooth muscle of ferret from trachea to terminal bronchioles, and marked differences were found in the longitudinal distribution of each receptor and in distribution of the various receptors in each caliber airway.

TL;DR: A statin enhances the anti-inflammatory effect of an inhaled corticosteroid in asthma, and this was mediated through the alteration of IDO activity in macrophages.

TL;DR: It seems likely that pharmacology, rather than molecular genetics, will remain the main approach to the further improvement of treatment for asthma, because new, more specific, therapies targeted at specific cytokines are less effective than corticosteroids, whereas more effective therapies carry a risk of side effects that may not be acceptable.

TL;DR: It has not been possible to identify any clinical factors that predict corticosteroid responsiveness in COPD patients in the large clinical trials, and there is increasing evidence that high doses of ICS may have detrimental effects on bones and may increase the risk of pneumonia.

TL;DR: Furosemide had no effect on resting lung function, but it caused a significant threefold reduction in sensitivity to MBS, and its effect on direct bronchoconstriction by the inhaled muscarinic agonist methacholine was studied.