P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
Papers
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Journal ArticleDOI
p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-κB-independent mechanism
Koremu K. Meja,Paul M. Seldon,Yasuyuki Nasuhara,Kazuhiro Ito,Peter J. Barnes,Mark A. Lindsay,Mark A. Giembycz +6 more
TL;DR: Results suggest that the generation of GM‐CSF by LPS‐stimulated human monocytes is regulated in a co‐operative fashion by p38 MAP kinase‐ and MKK‐1‐dependent signalling pathways independently of the activation of NF‐κB.
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Exhaled Nitric Oxide Is Increased in Asthma
Sergei A. Kharitonov,Deborah H Yates,David R. Springall,Lee D.K. Buttery,Julia M. Polak,Richard A. Robbins,Peter J. Barnes +6 more
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Glucocorticoids reverse IL-1β-induced impairment of β-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases
TL;DR: It is proposed that both the decrease in AC activity and the increase in GRK activity, which are reversed by dexamethasone, may underlie β2‐adrenoceptor desensitization.
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IL-1β and TNF-α Regulation of the Adenosine Receptor (A2A) Expression: Differential Requirement for NF-κB Binding to the Proximal Promoter
Silvana Morello,Kazuhiro Ito,Satoshi Yamamura,Kang Yun Lee,Elen Jazrawi,Patricia DeSouza,Peter J. Barnes,Carla Cicala,Ian M. Adcock +8 more
TL;DR: The results directly implicate a major role for NF-κB in the regulation of A2AR gene transcription by IL-1β and TNF-α but suggest that the effects of T NF-α on A2 AR gene transcription are not mediated through the proximal promoter.
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Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig.
TL;DR: NK1 receptor-mediated mechanisms may contribute to SP- and BK-induced airway microvascular leakage and SP-induced bronchoconstriction and hypotension and these mechanisms are not important in the acute airway responses induced by inhaled allergen.