P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
Papers
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Journal ArticleDOI
p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma.
TL;DR: In vitro corticosteroid sensitivity on TNF-α-induced IL-8 production was significantly lower in patients with severe asthma than in healthy volunteers and patients with mild asthma, and p38 MAPK-γ inhibition by LABAs has potential for the treatment of severe asthma.
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Phosphodiesterase expression in human epithelial cells
TL;DR: Epithelial PDE may be an important target for PDE4 inhibitors in the development of the control of asthmatic inflammation, particularly when delivered via the inhaled route.
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Circulating catecholamines in acute asthma.
TL;DR: A surprising failure of the plasma adrenaline concentration to increase during the stress of an acute attack of asthma was unexplained and contrasts with the pronounced rise in plasma adrenaline and noradrenaline concentrations in acute myocardial infarction, heart failure, and septicaemia.
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PRODUCTION OF 6-OXO-PGF1α BY HUMAN LUNG IN VIVO
TL;DR: The production of 6-oxo-PGF1 alpha, a stable hydrolysis product of prostacyclin (PGI2), by human lung was demonstrated in five adults and the lowest increase on passage through the lung was noted in a woman on oral contraceptives.
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Muscarinic receptor subtypes mediating vasodilation in the pulmonary artery.
TL;DR: It is demonstrated that the muscarinic receptor on the rat pulmonary artery endothelium which mediates vasodilation is of the M3 subtype and cannot account for the high proportion of M1 receptors identified in lung homogenates.