P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
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Journal ArticleDOI
Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease.
Amy E Dunne,Theerasuk Kawamatawong,Peter Fenwick,Ceri M Davies,Hannah Tullett,Peter J. Barnes,Louise E. Donnelly +6 more
TL;DR: It is suggested that roflumilast inhibits neutrophil chemotaxis directly via a cAMP‐mediated mechanism requiring activation of Epac1 and that Epac 1 activators could reduce COPD neutrophilic inflammation.
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Modulation of bradykinin responses in airway smooth muscle by epithelial enzymes
TL;DR: The contractile effect of BK on airway smooth muscle may be inhibited by a protective role of epithelium, due to release of relaxant prostanoids and by degradation by epithelial NEP.
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Histamine H3 receptors modulate antigen-induced bronchoconstriction in guinea pigs
TL;DR: It is concluded that H3 receptors might play a role in regulation of antigen-induced response in the airways, suggesting that OA-induced bronchoconstrictor responses are histamine (H1 receptor) mediated.
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Overview of Neural Mechanisms in Asthma
TL;DR: The neurotransmitter of bronchodilator nerves is now identified as nitric oxide and this mechanism may be impaired during asthma exacerbations, and neurogenic inflammation, due to release of neuropeptides from sensory nerves, may contribute and amplify the inflammation in asthmatic airways.
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Glucocorticoids reduce tachykinin NK2 receptor expression in bovine tracheal smooth muscle
TL;DR: It is suggested that glucocorticoids act on glucocortsicoid receptors to decrease tachykinin NK2 receptor expression by decreasing the rate of tachy KinNK2 receptor gene transcription.