P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
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Lung Neutrophil Burden Correlates With Increased Pro-Inflammatory Cytokines and Decreased Lung Function in Individuals With α1-Antitrypsin Deficiency
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Enhanced noradrenaline response in cardiomyopathic hamsters: possible relation to changes in adrenoceptors studied by radioligand binding
TL;DR: Possible explanations for the raise response to noradrenaline in cardiomyopathic hamsters include and increased concentration of noradRenaline in the synaptic cleft due to defective neuronal uptake and / or stimulation of an augmented population of alpha 1-(postsynaptic) adrenoceptors.
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Bromodomain and Extraterminal Proteins Suppress NF-E2–Related Factor 2–Mediated Antioxidant Gene Expression
Charalambos Michaeloudes,Nicolas Mercado,Colin Clarke,Pankaj K. Bhavsar,Ian M. Adcock,Peter J. Barnes,Kian Fan Chung +6 more
TL;DR: BET proteins, particularly Brd2 and Brd4, may play a key role in the regulation of Nrf2-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress–mediated diseases.
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Exhaled carbon monoxide in asthmatics: a meta-analysis
Jingying Zhang,Xin Yao,Rongbin Yu,Jianling Bai,Yun Sun,Mao Huang,Ian M. Adcock,Peter J. Barnes +7 more
TL;DR: Exhaled carbon monoxide (eCO) measurement is cheap and has been proposed to reflect airway inflammation and oxidative stress but current data are conflicting, and eCO is elevated in asthmatics but levels only partially reflect disease severity and control.
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Hypoxia-inducible Factor 1α Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription
Catherine Elisabeth Charron,Pai-Chien Chou,Pai-Chien Chou,David J.C. Coutts,Vaibhav Kumar,Masako To,Kenichi Akashi,Liao Pinhu,Mark J.D. Griffiths,Ian M. Adcock,Peter J. Barnes,Kazuhiro Ito +11 more
TL;DR: Hypoxia induces corticosteroid-insensitive inflammation via reduced transcription of histone deacetylase-2 (HDAC2) in lung epithelial and macrophage cells through binding of the transcription factor hypoxia-inducible factor (HIF) 1α to a HIF response element at position −320, resulting in reduced polymerase II binding at the site.