P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
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New treatments for copd
TL;DR: A better understanding of the cellular and molecular mechanisms that are involved in the underlying inflammatory and destructive processes has revealed several new targets for which drugs are now in development, and the prospects for finding new treatments are good.
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Increased Interleukin-4 and Decreased Interferon-γ in Exhaled Breath Condensate of Children with Asthma
TL;DR: Exhaled breath condensate analysis shows an increased ratio of IL-4/IFN-gamma, consistent with predominance of Th2 cells in airways of children with asthma, which may have a useful role in studying allergic inflammation in childhood asthma.
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Mechanisms of Action of Glucocorticoids in Asthma
TL;DR: Although steroids are the most effective therapy known for asthma, their precise mechanism of action is not yet understood and the only limitation to their use is side effects, but recent evidence suggests that this is not a problem for most patients.
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Regulation of Th2 Cytokine Genes by p38 MAPK-Mediated Phosphorylation of GATA-3
Kittipong Maneechotesuwan,Yao Xin,Kazuhiro Ito,Elen Jazrawi,Kang Yun Lee,Omar S. Usmani,Peter J. Barnes,Ian M. Adcock +7 more
TL;DR: Using small interfering RNA to knock down GATA-3, its critical role in regulating IL-4, IL-5, and IL-13 release from a human T cell line is demonstrated and this novel mechanism may provide new approaches to treating allergic diseases.
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L-arginine increases exhaled nitric oxide in normal human subjects.
TL;DR: The results suggest that an increase in the amount of substrate for Nitric oxide synthase can increase the formation of endogenous nitric oxide, which may have therapeutic relevance in diseases in which there is defective production ofNitric oxide.