Peter J. Barnes

TL;DR: It is suggested that expression of PKIα in susceptible cells provides a simple and unambiguous way to assess the role of PKA in cAMP signaling and to probe the mechanism of action of other drugs and cAMP-dependent responses where the participation of Pka is equivocal.

TL;DR: Prazosin significantly (p 1 -adrenoceptor) may be involved in the pathogenesis of exercise-induced asthma either by facilitation of mast-cell mediator release or by direct contraction of bronchial smooth muscle.

TL;DR: Results indicate that in normal subjects BK stimulates predominantly vascular permeability, and that cholinergic reflexes do not significantly contribute to their BK-induced nasal secretion, and suggests that BK is more adept at directly inducing vascular effects than glandular secretion of nociceptive nerve-parasympathetic reflexes.

TL;DR: It is suggested that TLR3 stimulation is involved in corticosteroid-refractory airway inflammation in lung, which is enhanced by cigarette smoking, and this may provide a model for understanding virus-induced exacerbations in COPD and their therapy.

TL;DR: Evaluated the potential of isorhapontigenin, another dietary polyphenol, as a novel anti‐inflammatory agent for COPD by examining its effects in vitro and pharmacokinetics in vivo.