P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
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Journal ArticleDOI
Enhanced monocyte migration to CXCR3 and CCR5 chemokines in COPD
Cláudia Henrique da Costa,Suzanne L. Traves,Susan J. Tudhope,Peter Fenwick,Kylie B. R. Belchamber,Richard Russell,Peter J. Barnes,Louise E. Donnelly +7 more
TL;DR: Both monocytes and lymphocytes cooperate to enhance migration towards CXCR3 chemokines and CCL5, which may contribute to increased numbers of macrophages and T-cells in the lungs of COPD patients, and inhibition of recruitment using selective antagonists might be a treatment to reduce the inflammatory response in COPD.
Journal ArticleDOI
Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease.
Patrick Mallia,Patrick Mallia,Jessica Webber,Simren K. Gill,Maria-Belen Trujillo-Torralbo,Maria Adelaide Calderazzo,Lydia J. Finney,Eteri Bakhsoliani,Hugo Farne,Aran Singanayagam,Aran Singanayagam,Joseph Footitt,Richard J. Hewitt,Tatiana Kebadze,Julia Aniscenko,Vijay Padmanaban,Philip L. Molyneaux,Ian M. Adcock,Peter J. Barnes,K Ito,Sarah L. Elkin,Sarah L. Elkin,Onn Min Kon,Onn Min Kon,William O.C.M. Cookson,Miriam F Moffat,Sebastian L. Johnston,Sebastian L. Johnston,John S. Tregoning +28 more
TL;DR: Airway glucose concentrations are increased in patients with stable COPD and further increased during COPD exacerbations, which has important implications for the development of nonantibiotic therapeutic strategies for the prevention or treatment of bacterial infection in patientswith COPD.
Journal ArticleDOI
Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells☆
Christos Rossios,Yasuo To,Masako To,Misako Ito,Peter J. Barnes,Ian M. Adcock,Malcolm Johnson,Malcolm Johnson,Kazuhiro Ito +8 more
TL;DR: FF showed superior effects to FP in peripheral blood mononuclear cells from patients with COPD and also in U937 cells or primary bronchial epithelial cells under conditions of oxidative stress, and has potential clinical implications for the control of inflammation in respiratory diseases, such as COPD.
Journal Article
Nonadrenergic, noncholinergic airway inhibitory nerves
TL;DR: Use of antagonists or inhibitors of putative neurotransmitters, and molecular biological techniques will be useful in defining both the physiological and pathophysiological roles of NANC inhibitory nerves in the airways.
Journal Article
Tachykinin-induced phosphoinositide breakdown in airway smooth muscle and epithelium: relationship to contraction
TL;DR: In airway smooth muscle, it was found that tachykinins elicited phosphoinositide breakdown with an order of potency similar to that for contractile response, and in epithelium, SP alone elicited a significant phosphoinposide breakdown, suggesting that epithelial receptors to tachy Kinins may be of the NK1 subtype.