P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
Papers
More filters
Journal ArticleDOI
Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release
Joanna E. Chivers,Lisa M. Cambridge,Matthew C. Catley,Judith C.W. Mak,Louise E. Donnelly,Peter J. Barnes,Robert Newton +6 more
TL;DR: Two pharmacologically distinct mechanisms of glucocorticoid-dependent repression of prostaglandin E2 release are revealed: first, arachidonic acid repression is mimicked by RU486 and, second, repression of COX/PGES is antagonized by RU485.
Journal ArticleDOI
IL-10: a key regulator of allergic disease
TL;DR: # $ % & # % # # # -'./ 0 0 # '# $ 2 1 ( 2 )& # %# # 6 3 78.'5* 9 + ( )&# % # + # : % + # .;*0 % + -<;= 0 # ( ) & '# # # @ 7 & # # % + & % # <42'
Journal ArticleDOI
Chronic obstructive pulmonary disease and lung cancer: a lethal association.
Peter J. Barnes,Ian M. Adcock +1 more
TL;DR: Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema for chronic obstructive pulmonary disease and links functional decline of telomeres, mitochondria and stem cells during ageing.
Book ChapterDOI
Epidemiology, Risk Factors and Pathophysiology
TL;DR: Chronic Obstructive Pulmonary Disease (COPD) is a preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients.
Journal ArticleDOI
Oxidative stress modulates theophylline effects on steroid responsiveness.
John A. Marwick,Gillian Wallis,Koremu Meja,Bernhard Kuster,Tewis Bouwmeester,Probir Chakravarty,Danielle Fletcher,Paul A. Whittaker,Peter J. Barnes,Kazuhiro Ito,Ian M. Adcock,Paul Kirkham,Paul Kirkham +12 more
TL;DR: It is demonstrated that a low concentration of theophylline restores corticosteroid repression of pro-inflammatory mediator release and histone acetylation in oxidant exposed cells, however the mechanism remains unknown.