P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
Papers
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Journal ArticleDOI
Asthma-COPD Overlap
TL;DR: The patients who receive a primary diagnosis of asthma who have some features of COPD are better considered as phenotypes of asthma, and this condition may be better to refer to asthma-COPD overlap (ACO), rather than ACOS.
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Endothelins and pulmonary diseases
TL;DR: Findings implicate ETs in various pulmonary diseases and suggest that ET antagonists may be useful in their treatment, as well as suggesting a predominance of ETA receptors.
Journal ArticleDOI
Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells.
Martin Fuhrmann,Hans-Ulrich Jahn,Joachim Seybold,Claus Neurohr,Peter J. Barnes,Stefan Hippenstiel,Hans Joachim Kraemer,Norbert Suttorp +7 more
TL;DR: The data suggest that Pde isoenzymes are important in airway inflammation and that PDE inhibitors exert anti-inflammatory effects by acting on AEC.
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Chronic heart failure in the guinea pig increases cardiac α1- and β-adrenoceptors
TL;DR: Congestive heart failure due to chronic pressure overload results in compensatory augmentation of α1- and β-adrenoceptor numbers, compared with sham-operated guinea pigs.
Journal ArticleDOI
IL-1β-dependent activation of NF-κB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase
Matthew C. Catley,Joanna E. Chivers,Lisa M. Cambridge,Neil S. Holden,Donna M. Slater,Karl J. Staples,Martin W. Bergmann,Peter Löser,Peter J. Barnes,Robert Newton +9 more
TL;DR: A substantial role for NF‐κB is demonstrated in the co‐ordinate induction of COX‐2, mPGES and in the corresponding release of PGE2 by IL‐1β, however, other pathways are primarily responsible for P GE2 release induced by PMA.