P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
Papers
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Histone acetylation and deacetylation: importance in inflammatory lung diseases
TL;DR: The reduction in histone deacetylase activity can be restored by theophylline, which may be able to reverse steroid resistance in chronic obstructive pulmonary disease and other inflammatory diseases.
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Reactive oxygen species and airway inflammation.
TL;DR: The role of reactive oxygen species in airway disease has been largely neglected, but appears to be an important area for future study and radical scavengers or antioxidants could play a useful role in therapy.
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Nitric oxide and asthmatic inflammation
Peter J. Barnes,Foo Y. Liew +1 more
TL;DR: It is argued that the development of specific iNOS inhibitors may represent a novel therapeutic approach for asthma and other allergic diseases.
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Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size.
TL;DR: Regional targeting of inhaled beta2-agonist to the proximal airways is more important than distal alveolar deposition for bronchodilation and can appreciably enhance inhaled drug therapy and may have implications for developing future inhaled treatments.
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COPD as a Disease of Accelerated Lung Aging
Kazuhiro Ito,Peter J. Barnes +1 more
TL;DR: The evidence that accelerating aging of lung in response to oxidative stress is involved in the pathogenesis and progression of COPD, particularly emphysema is reviewed.