P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
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Intranasal administration of eotaxin increases nasal eosinophils and nitric oxide in patients with allergic rhinitis
TL;DR: It is shown that eotaxin causes chemotaxis of eosinophils with a clinically symptomatic inflammatory response in the nasal mucosa and that eos inophil recruitment accompanies an increase in nasal NO, contributing to oxidative stress.
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Loss of Control of Asthma Following Inhaled Corticosteroid Withdrawal Is Associated With Increased Sputum Interleukin-8 and Neutrophils
Kittipong Maneechotesuwan,Sarah Essilfie-Quaye,Sergei A. Kharitonov,Ian M. Adcock,Peter J. Barnes +4 more
TL;DR: Rapid withdrawal of inhaled corticosteroids results in an exacerbation of asthma that is preceded by an increase in sputum neutrophils and IL-8 concentrations, in contrast to a increase in eosinophils reported in previous studies in which inhaled steroids are slowly tapered.
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Effect of arginine on mucociliary function in primary ciliary dyskinesia.
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Autoradiographic visualization of bradykinin receptors in human and guinea pig lung.
Judith C.W. Mak,Peter J. Barnes +1 more
TL;DR: Autoradiography revealed that BK receptors were widely distributed in human and guinea pig lung, with dense labelling over bronchial and pulmonary blood vessels of all sizes and in the lamina propria immediately subjacent to the basal epithelial cell layer in large airways.
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A sensitive and specific radiometric method for the measurement of plasma histamine in normal individuals.
TL;DR: A radioenzymatic method for assaying histamine using histamine-N-methyltransferase from guinea pig brain was modified to increase its sensitivity, precision, and specificity by incorporation of a thin-layer chromatography step and use of Nα-methyl histamine as an internal standard in each sample.