P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
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Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways.
TL;DR: It is concluded that loop diuretics inhibit both cholinergic and excitatory NANC neurotransmission in guinea pig airways and that this effect may be related to their inhibitory effects on the sodium-potassium-chloride cotransporter.
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Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats.
Michael Salmon,David A. Walsh,Tung Jung Huang,Peter J. Barnes,Thomas B. Leonard,Douglas W. P. Hay,K. Fan Chung +6 more
TL;DR: The data indicate that the cysteinyl leukotrienes are important mediators in allergen‐induced ASM cell DNA synthesis and ASM thickening in rats, while both LTB4 and cysteiny leukOTrienes contribute to ASM Thickening and eosinophil recruitment following repeated allerGEN exposure.
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The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1β-dependent PGE2 release via mechanistically distinct processes
TL;DR: It is concluded that the MEK1, MEK2 and p38 MAP kinase inhibitors, PD098059, UO126 and SB203580, are highly potent in respect of inflammatory PG release and act via mechanistically distinct processes, which may have anti‐inflammatory benefits.
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Current issues for establishing inhaled corticosteroids as the antiinflammatory agents of choice in asthma
TL;DR: The efficacy and safety of inhaled corticosteroids are compared in this article, and inhaled Corticosteroid therapy is also compared with other therapies.