Peter J. Barnes

TL;DR: Routine serial measurements of F(E)NO for clinical asthma management does not appear warranted and the role of add-on monitoring of exhaled NO to GOLD management guidelines is less clear because of the absence of conclusive doubleblind, randomized, control trial studies concerning potential clinical benefits in the management of COPD.

TL;DR: Part 1 Innervation of the Airways: Neuropeptides and Classic Innervation - Neural Structures in Human Airways Functional Autonomic Innervation in the Airways - The Cholinergic and Adrenergic Systems NeuropePTides in the Lower Airways Investigated by Modem Microscopy Neural Control of the Upper Respiratory Tract Peptide Biosynthesis and Secretion.

TL;DR: In this paper , the authors investigated whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with cellular senescence and SASP, and they demonstrated that in severe COVID-19, alveolar type 2 (AT2) cells infected by SARS-coV2 exhibit a proinflammatory phenotype.

TL;DR: The inability of drugs which increase tissue cyclic GMP content and exhibit anti‐spasmogenic activity to inhibit methacholine‐stimulated Ins(1,4,5)P3 formation suggests that, unlike vascular smooth muscle, cyclicGMP‐dependent mechanisms do not regulate receptor‐mediated phosphoinositide hydrolysis in BTSM.

TL;DR: The inflammatory response in COPD is essentially steroid-resistant so that alternative anti-inflammatory treatments are needed and new therapeutic approaches to prevent disease progression are urgently needed.