P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
Papers
More filters
Journal ArticleDOI
GM-CSF expression in pulmonary epithelial cells is regulated negatively by posttranscriptional mechanisms.
Robert Newton,Robert Newton,Karl J. Staples,Lorraine A. Hart,Peter J. Barnes,Martin W. Bergmann +5 more
TL;DR: The data suggest the existence of inhibitory pathways that posttranscriptionally regulate GM-CSF expression via new protein synthesis and D609- and PDTC-sensitive steps, which may have important clinical implications.
Journal ArticleDOI
Anti-leukotrienes: here to stay?
TL;DR: In clinical practice, anti-leukotrienes have not proved to be very useful, and they are less cost-effective than other treatments, so will remain as a weak second-line therapy.
Journal ArticleDOI
Desensitization of the histamine H1-receptor and transcriptional down-regulation of histamine H1-receptor gene expression in bovine tracheal smooth muscle
TL;DR: A PKC‐mediated desensitization of the histamine H1‐receptor in BTSM and a transcriptional down‐regulation of the Histamines H1-receptor gene expression, which requires new protein synthesis, are shown.
Journal ArticleDOI
The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma
TL;DR: Oral MEM 1414, a novel PDE4 inhibitor, significantly reduces the late response following inhaled allergen challenge and was associated with a typical adverse event profile of PDE 4 inhibitors, namely nausea and vomiting although these were mild side effects.
Journal ArticleDOI
Effect of maturation on histamine-induced airflow obstruction and airway microvascular leakage in guinea pig airways
Hirokazu Arakawa,Kenichi Tokuyama,Tatsuya Yokoyama,Hiroyuki Mochizuki,Akihiro Morikawa,Takayoshi Kuroume,Peter J. Barnes +6 more
TL;DR: Results suggest that i.v. histamine specifically causes a greater degree of airway microvascular leakage in peripheral airways but induces less smooth muscle contraction in the airways of immature guinea pigs than in theAirways of adult animals.