P
Peter J. Barnes
Researcher at National Institutes of Health
Publications - 1554
Citations - 177909
Peter J. Barnes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 194, co-authored 1530 publications receiving 166618 citations. Previous affiliations of Peter J. Barnes include University of Nebraska Medical Center & Novartis.
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Chronic obstructive pulmonary disease: new opportunities for drug development.
TL;DR: Potential new drugs for chronic obstructive pulmonary disease are considered, including inflammatory mediators, proteases and adhesion molecules.
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Superinduction of COX-2 mRNA by cycloheximide and interleukin-1β involves increased transcription and correlates with increased NF-κB and JNK activation
TL;DR: Data are consistent with negative feed‐back involving down‐regulation of NF‐κB by de novo IκBα synthesis and suggest that JNK activation may also be down‐regulated by a cycloheximide sensitive process.
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Nasal and Exhaled Nitric Oxide Is Reduced in Adult Patients With Cystic Fibrosis and Does Not Correlate With Cystic Fibrosis Genotype
TL;DR: Despite the airway inflammation that is characteristic of CF, both nasal and exhaled NO were reduced, and the effect of CF genotype and respiratory tract infection on this measurement may be of clinical importance.
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Faster rise of exhaled breath temperature in asthma: a novel marker of airway inflammation?
TL;DR: Asthmatic subjects have elevated Deltae degrees T, which may represent a novel, noninvasive means of measuring airway blood flow and inflammation in asthma.
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Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis
TL;DR: This study shows that the measurement of exhaled CO is of potential value as an indicator of exacerbations in patients with CF and could be used as a simple method to monitor the course of the disease.