Richard K. Wilson

TL;DR: A scoring algorithm is developed to prioritize potential causal variants within a family according to segregation with the phenotype, population frequency, predicted effect, and gene expression in the tissue(s) of interest, and to narrow the search space in families with multiple affected individuals.

TL;DR: Analysis of 24 synteny breakpoints in the white-cheeked gibbon provides a model for a replication-dependent repair mechanism for double-strand breaks (DSBs) at rearrangement sites and insights into the structure and formation of primate segmental duplications at sites of genomic rearrangements during evolution.

TL;DR: Mutational and neoantigen load, and T-cell infiltrate within the tumor, were associated with outcome of sequential checkpoint inhibition using nivolumab then ipilimumab, but not when ipILimumab was administered before nivlumab.

TL;DR: A high-resolution genetic linkage map of the domestic cat genome based on genotyping 453 domestic cats from several multi-generational pedigrees on the Illumina 63K SNP array is described, which describes features of the recombination landscape, including a massive recombination desert that parallels a similar desert on the porcine X chromosome in both size and physical location.

TL;DR: A mouse sarcoma model expressing SS18-SSX1 is reported, complementing the authors' prior model, and two possible roles for native SSX2 in synovial sarcomagenesis are explored.