R
Richard K. Wilson
Researcher at Nationwide Children's Hospital
Publications - 501
Citations - 294778
Richard K. Wilson is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 173, co-authored 463 publications receiving 260000 citations. Previous affiliations of Richard K. Wilson include University of Washington & St. Jude Children's Research Hospital.
Papers
More filters
Journal ArticleDOI
Cancer genome sequencing: a review
TL;DR: Several areas within cancer genomics are being transformed by the application of new technology, and in the process are dramatically expanding the authors' understanding of this disease.
Journal ArticleDOI
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome
Elliott H. Margulies,Gregory M. Cooper,Gregory M. Cooper,George Asimenos,Daryl J. Thomas,Colin N. Dewey,Colin N. Dewey,Adam Siepel,Adam Siepel,Ewan Birney,Damian Keefe,Ariel S. Schwartz,Minmei Hou,James Taylor,Sergey Nikolaev,Juan I. Montoya-Burgos,Ari Löytynoja,Simon Whelan,Fabio Pardi,Tim Massingham,James B. Brown,Peter J. Bickel,Ian Holmes,James C. Mullikin,Abel Ureta-Vidal,Benedict Paten,Eric A. Stone,Kate R. Rosenbloom,W. James Kent,Gerard G. Bouffard,Xiaobin Guan,Nancy F. Hansen,Jacquelyn R. Idol,Valerie Maduro,Baishali Maskeri,Jennifer C. McDowell,Morgan Park,Pamela J. Thomas,Alice C. Young,Robert W. Blakesley,Donna M. Muzny,Erica Sodergren,David A. Wheeler,Kim C. Worley,Huaiyang Jiang,George M. Weinstock,Richard A. Gibbs,Tina Graves,Robert S. Fulton,Elaine R. Mardis,Richard K. Wilson,Michele Clamp,James Cuff,Sante Gnerre,David B. Jaffe,Jean L. Chang,Kerstin Lindblad-Toh,Eric S. Lander,Eric S. Lander,Angie S. Hinrichs,Heather Trumbower,Hiram Clawson,Ann S. Zweig,Robert M. Kuhn,Galt P. Barber,Rachel A. Harte,Donna Karolchik,Matthew A. Field,Richard A. Moore,Carrie A. Matthewson,Jacqueline E. Schein,Marco A. Marra,Stylianos E. Antonarakis,Serafim Batzoglou,Nick Goldman,Ross C. Hardison,David Haussler,David Haussler,Webb Miller,Lior Pachter,Eric D. Green,Arend Sidow +81 more
TL;DR: The quantitative and qualitative trade-offs concomitant with alignment method choice and the levels of technical error that need to be accounted for in applications that require multisequence alignments are described.
Journal ArticleDOI
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Tanja A. Gruber,Amanda Larson Gedman,Jinghui Zhang,Cary Koss,Suresh Marada,Huy Q. Ta,Shann Ching Chen,Xiaoping Su,Stacey K. Ogden,Jinjun Dang,Gang Wu,Vedant Gupta,Anna Andersson,Stanley Pounds,Lei Shi,John Easton,Michael I. Barbato,Heather L. Mulder,Jayanthi Manne,Jianmin Wang,Michael Rusch,Swati Ranade,Ramapriya Ganti,Matthew Parker,Jing Ma,Ina Radtke,Li Ding,Li Ding,Giovanni Cazzaniga,Andrea Biondi,Steven M. Kornblau,Farhad Ravandi,Hagop M. Kantarjian,Stephen D. Nimer,Konstanze Döhner,Hartmut Döhner,Timothy J. Ley,Timothy J. Ley,Paola Ballerini,Sheila A. Shurtleff,Daisuke Tomizawa,Souichi Adachi,Yasuhide Hayashi,Akio Tawa,Lee Yung Shih,Der Cherng Liang,Jeffrey E. Rubnitz,Ching-Hon Pui,Elaine R. Mardis,Elaine R. Mardis,Richard K. Wilson,Richard K. Wilson,James R. Downing +52 more
TL;DR: In this article, the authors performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated their findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples.
Journal ArticleDOI
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia
Jinghui Zhang,Kelly McCastlain,Hiroki Yoshihara,Beisi Xu,Yunchao Chang,Michelle L. Churchman,Gang Wu,Yongjin Li,Lei Wei,Ilaria Iacobucci,Yu Liu,Chunxu Qu,Ji Wen,Michael N. Edmonson,Debbie Payne-Turner,Kerstin B. Kaufmann,Shin-ichiro Takayanagi,Shin-ichiro Takayanagi,Erno Wienholds,Esmé Waanders,Esmé Waanders,Panagiotis Ntziachristos,Sofia Bakogianni,Jingjing Wang,Iannis Aifantis,Iannis Aifantis,Kathryn G. Roberts,Jing Ma,Guangchun Song,John Easton,Heather L. Mulder,Xiang Chen,Scott Newman,Xiaotu Ma,Michael Rusch,Pankaj Gupta,Kristy Boggs,Bhavin Vadodaria,James Dalton,Yanling Liu,Marcus L Valentine,Li Ding,Charles Lu,Robert S. Fulton,Lucinda Fulton,Yashodhan Tabib,Kerri Ochoa,Meenakshi Devidas,Deqing Pei,Cheng Cheng,Jun J. Yang,William E. Evans,Mary V. Relling,Ching-Hon Pui,Sima Jeha,Richard C. Harvey,I-Ming L. Chen,Cheryl L. Willman,Guido Marcucci,Clara D. Bloomfield,Jessica Kohlschmidt,Krzysztof Mrózek,Elisabeth Paietta,Martin S. Tallman,Wendy Stock,Matthew C. Foster,Janis Racevskis,Jacob M. Rowe,Selina M. Luger,Steven M. Kornblau,Sheila A. Shurtleff,Susana C. Raimondi,Elaine R. Mardis,Richard K. Wilson,John E. Dick,Stephen P. Hunger,Mignon L. Loh,James R. Downing,Charles G. Mullighan +78 more
TL;DR: A unique paradigm of transcription factor deregulation in leukemia is illustrated in which DUX4 deregulation results in loss of function of ERG, either by deletion or induced expression of an isoform that is a dominant-negative inhibitor of wild-type ERG function.
Journal ArticleDOI
Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.
Corey T. Watson,Karyn Meltz Steinberg,John Huddleston,René L. Warren,Maika Malig,Jacqueline E. Schein,A. Jeremy Willsey,Jeffrey B. Joy,Jamie K. Scott,Tina Graves,Richard K. Wilson,Robert A. Holt,Evan E. Eichler,Evan E. Eichler,Felix Breden +14 more
TL;DR: This work presents the most complete haplotype of IGHV, IGHD, and IGHJ gene regions derived from a single chromosome, representing an alternate assembly of ∼1 Mbp of high-quality finished sequence, and characterize four large germline copy-number variants (CNVs).