R
Richard K. Wilson
Researcher at Nationwide Children's Hospital
Publications - 501
Citations - 294778
Richard K. Wilson is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 173, co-authored 463 publications receiving 260000 citations. Previous affiliations of Richard K. Wilson include University of Washington & St. Jude Children's Research Hospital.
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Journal Article
Variant prioritization and linkage mapping using whole-exome sequencing data for families with autosomal dominant retinitis pigmentosa (adRP)
Daniel C. Koboldt,David E. Larson,Lori S. Sullivan,Sara J. Bowne,Robert S. Fulton,Erica Sodergren,Susan H. Blanton,Stephen P. Daiger,Richard K. Wilson,George M. Weinstock +9 more
Journal ArticleDOI
Mutations In the DNA Methyltransferase Gene DNMT3A Are Highly Recurrent In Patients with Intermediate Risk Acute Myeloid Leukemia, and Predict Poor Outcomes
Timothy J. Ley,Li Ding,Matthew J. Walter,Michael D. McLellan,Tamara Lamprecht,David E. Larson,Cyriac Kandoth,Jacqueline E. Payton,Jack Baty,John S. Welch,Chris Harris,Cheryl F. Lichti,Raymond R. Townsend,Robert S. Fulton,David J. Dooling,Daniel C. Koboldt,Heather Schmidt,Qunyuan Zhang,John R. Osborne,Ling Lin,Michelle O'Laughlin,Joshua F. McMichael,Kim D. Delehaunty,Sean McGrath,Lucinda Fulton,Vincent Magrini,Tammi L. Vickery,Jasreet Hundal,Lisa Cook,Joshua J. Conyers,Gary W. Swift,Jerry P. Reed,Patricia A. Alldredge,Todd Wylie,Jason Walker,Joelle Kalicki-Veizer,Mark A. Watson,Sharon Heath,William D. Shannon,Nobish Varghese,Rakesh Nagarajan,Peter Westervelt,Michael H. Tomasson,Daniel C. Link,Timothy A. Graubert,John F. DiPersio,Elaine R. Mardis,Richard K. Wilson +47 more
TL;DR: A novel frameshift mutation in DNMT3A, one of the three genes in humans that encodes a DNA methyltransferase that catalyzes the addition of methyl groups to cytosine within CpG dinucleotides, is discovered.
Proceedings ArticleDOI
The SAFRR Tsunami Scenario
Keith Porter,Lucile M. Jones,S. Ross,Jose C. Borrero,J. Bwarie,D. Dykstra,Eric L. Geist,Laurie A. Johnson,Stephen H. Kirby,Kate Long,Patrick J. Lynett,Kevin P. Miller,Carl E. Mortensen,S. C. Perry,Geoffrey S. Plumlee,C. R. Real,Lewis D Ritchie,Charles Scawthorn,Hong Kie Thio,Anne Wein,P. Whitmore,Richard K. Wilson,Nathan J. Wood +22 more
TL;DR: The SAFRR Tsunami Scenario describes potential impacts of a hypothetical, but realistic, tsunami affecting California (as well as the west coast of the United States, Alaska, and Hawaii) for the purpose of informing planning and mitigation decisions by a variety of stakeholders as discussed by the authors.
Journal ArticleDOI
Chromatin Immunoprecipitation of GFP-Tagged PML-Rara Coupled to High-Throughput Next Generation Sequencing.
Nicole R. Grieselhuber,Jahangheer S. Shaik,Li-Wei Chang,Sean McGrath,Lukas D. Wartman,Rakesh Nagarajan,Richard K. Wilson,Elaine R. Mardis,Timothy J. Ley +8 more
TL;DR: The results suggest that PML-RARA has an extended repertoire of genomic DNA binding sites compared to wild-type RARA, reflecting novel gain-of-function properties of the fusion protein.
Journal ArticleDOI
Detection of Novel Mutations In MDS/AML by Whole Genome Sequencing
Matthew J. Walter,Dong Shen,Li Ding,Jin Shao,Sarah E. Witowski,Ken Chen,Daniel C. Koboldt,David J. Dooling,Rachel Maupin,Robert S. Fulton,Heather Schmidt,Michelle O'Laughlin,Michael D. McLellan,John L. Frater,Peter Westervelt,John F. DiPersio,Elaine R. Mardis,Richard K. Wilson,Timothy J. Ley,Timothy A. Graubert +19 more
TL;DR: WGS of paired DNA samples from normal (skin) and tumor (bone marrow) specimens from a patient with MDS-derived AML identified 22 somatic SNVs and 10 mutations that were present in both the MDS and AML samples, suggesting that the underlying heterogeneity that is common in de novo MDS persists during transformation to AML.