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Richard K. Wilson
Researcher at Nationwide Children's Hospital
Publications - 501
Citations - 294778
Richard K. Wilson is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 173, co-authored 463 publications receiving 260000 citations. Previous affiliations of Richard K. Wilson include University of Washington & St. Jude Children's Research Hospital.
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Journal ArticleDOI
A physical map of human chromosome 14.
Thomas Brüls,Gabor Gyapay,Jean Louis Petit,François Artiguenave,Virginie Vico,Shizen Qin,Aye Mon Tin-Wollam,Corinne Da Silva,Delphine Muselet,Delphine Mavel,Eric Pelletier,Michael J. Levy,Asao Fujiyama,Fumihiko Matsuda,Richard K. Wilson,Lee Rowen,Leroy Hood,Jean Weissenbach,William Saurin,Roland Heilig +19 more
TL;DR: The construction of a tiling path of around 650 clones covering more than 99% of human chromosome 14 indicates that the sequence tag connector approach compares favourably with alternative mapping strategies.
Journal ArticleDOI
The construction and analysis of M13 libraries prepared from YAC DNA
M. Vaudin,Avtar Roopra,LaDeana W. Hillier,Ryan R. Brinkman,John Sulston,Richard K. Wilson,Robert H. Waterston +6 more
TL;DR: It is shown that sequencing at about 1-fold coverage, followed by database comparison (survey sequencing) offers a relatively quick method to determine the nature of previously uncharacterized cosmid or YAC clones.
Journal ArticleDOI
Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Eric J. Duncavage,Geoffrey L. Uy,Allegra A. Petti,Christopher A. Miller,Yi-Shan Lee,Bevan Tandon,Feng Gao,Catrina Fronick,Michelle O'Laughlin,Robert S. Fulton,Richard K. Wilson,Meagan A. Jacoby,Amanda F. Cashen,Lukas D. Wartman,Matthew J. Walter,Peter Westervelt,Daniel C. Link,John F. DiPersio,Timothy J. Ley,John S. Welch +19 more
TL;DR: Quantitative response evaluation in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDSs) relies on the morphologic quantification of bone marrow blasts, subject to the operator-dependent quality of BM collection and the interobserver variability.
Journal ArticleDOI
Theories and Applications for Sequencing Randomly Selected Clones
Michael C. Wendl,Marco A. Marra,LaDeana W. Hillier,Asif T. Chinwalla,Richard K. Wilson,Robert H. Waterston +5 more
TL;DR: It is concluded that the map-based approach outperforms random clone sequencing, except early in a project, and that simultaneous use of both strategies can be beneficial if a performance-based estimate for halting random clones is made.
Posted ContentDOI
High-Quality Assembly of an Individual of Yoruban Descent
Karyn Meltz Steinberg,Tina A. Graves-Lindsay,Valerie A. Schneider,Mark Chaisson,Chad Tomlinson,John Huddleston,Patrick Minx,Milinn Kremitzki,Derek Albrecht,Vincent Magrini,Sean McGrath,Archana Raja,Carl Baker,Lana Harshman,LaDeana W. Hillier,Françoise Thibaud-Nissen,Nathan Bouk,Amy Ly,Chris T. Amemiya,Joyce Tang,Evan E. Eichler,Robert S. Fulton,Wesley C. Warren,Deanna M. Church,Richard K. Wilson +24 more
TL;DR: This work uses PacBio single-molecule, real-time (SMRT) sequencing and BioNano genomic maps to construct the first de novo assembly of NA19240, a Yoruban individual from Africa, and demonstrates that diploid assembly has utility in improving the quality of de noVO human genome assemblies.