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Richard K. Wilson
Researcher at Nationwide Children's Hospital
Publications - 501
Citations - 294778
Richard K. Wilson is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 173, co-authored 463 publications receiving 260000 citations. Previous affiliations of Richard K. Wilson include University of Washington & St. Jude Children's Research Hospital.
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Journal ArticleDOI
The Characterization of the Phlebotomus papatasi Transcriptome
Jenica L. Abrudan,Marcelo Ramalho-Ortigao,Shawn T. O’Neil,Gwen Stayback,Mariha Wadsworth,Megan A. Bernard,Doug A Shoue,Scott J. Emrich,Phillip G. Lawyer,Shaden Kamhawi,Edgar Rowton,Michael J. Lehane,Paul A. Bates,Jesus G. Valenzeula,Chad Tomlinson,Elizabeth L. Appelbaum,Deborah Moeller,Brenda Thiesing,Rod J. Dillon,Sandra W. Clifton,Neil F. Lobo,Richard K. Wilson,Frank H. Collins,Mary Ann McDowell +23 more
TL;DR: The first global transcriptome analysis of the Old World vector of cutaneous leishmaniasis, Phlebotomus papatasi (Scopoli) is presented and this transcriptome will greatly improve the available genomic resources for P. papatasi and will provide essential information for annotation of the full genome.
Journal ArticleDOI
Resolving the Breakpoints of the 17q21.31 Microdeletion Syndrome with Next-Generation Sequencing
Andy Itsara,Lisenka E.L.M. Vissers,Karyn Meltz Steinberg,Kevin J. Meyer,Michael C. Zody,David A. Koolen,Joep de Ligt,Edwin Cuppen,Edwin Cuppen,Carl Baker,Choli Lee,Tina Graves,Richard K. Wilson,Robert B. Jenkins,Joris A. Veltman,Evan E. Eichler,Evan E. Eichler +16 more
TL;DR: The method provides a strategy for the identification of breakpoints within complex regions of the genome harboring high-identity and copy-number-polymorphic segmental duplication and mapped preferentially to gaps in the current reference genome assembly, which is resolved in this study.
Journal ArticleDOI
Building and Improving Reference Genome Assemblies
Karyn Meltz Steinberg,Valerie A. Schneider,Can Alkan,Michael J. Montague,Wesley C. Warren,Deanna M. Church,Richard K. Wilson +6 more
TL;DR: The relationship between sequencing technology improvements and assembly algorithm development and how these are applied to extend and improve human and nonhuman genome assemblies are discussed.
Journal ArticleDOI
Genomic Profiling of Lung Adenocarcinoma in Never-Smokers
Siddhartha Devarakonda,Yize Li,Fernanda Martins Rodrigues,Sumithra Sankararaman,Humam Kadara,Chandra Goparaju,Irena Lanc,Kymberlie H. Pepin,Saiama N. Waqar,Daniel Morgensztern,Jeffrey P. Ward,Ashiq Masood,Robert S. Fulton,Lucinda Fulton,Michael A. Gillette,Shankha Satpathy,Steven A. Carr,Ignacio I. Wistuba,Harvey I. Pass,Richard K. Wilson,Li Ding,Ramaswamy Govindan +21 more
TL;DR: In this article, the authors analyzed whole-exome and RNA-sequencing data of 160 tumor and normal lung adenocar cancer patients and found that approximately 10%-40% of patients with lung cancer report no history of tobacco smoking.
Journal ArticleDOI
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Elise Peterson Lu,Michael D. McLellan,Li Ding,Robert S. Fulton,Elaine R. Mardis,Richard K. Wilson,Christopher A. Miller,Peter Westervelt,John F. DiPersio,Daniel C. Link,Matthew J. Walter,Timothy J. Ley,Timothy A. Graubert +12 more
TL;DR: Exome sequencing and exome sequencing revealed that oligoclonal hematopoiesis emerged in Casp9-deficient bone marrow chimeras after alkylator exposure, suggesting that defects in apoptosis could be a key step in the pathogenesis ofAlkylator-associated secondary malignancies.